It:chlorphentermine

Chlorphentermine

Chlorphentermine is an anorectic (appetite suppressant) implicated in lipid storage disorders and pulmonary hypertension.

Structure

Chlorphentermine
Chemical name	1-(4-chlorophenyl)-2-methyl-propan-2-amine hydrochloride
CAS nummber	151-06-4
Chemical formula	C₁₀H₁₅Cl₂N
Molecular mass	220.14g mol^-1
SMILES	CC(N)(C)CC1=CC=C(Cl)C=C1.[H]Cl

Synthesis

The first step is performed under basic conditions. The second step is a catalysed reduction reaction.

IR Spectrum

Effects

The effects of chlorphentermine on rats have been extensively studied. Chronic administration of chlorphentermine to rats resulted in a reduction of body weight compared to a normal control group. The weight of the heart, liver, kidney, and spleen was less in the treated group while the weight of the lungs was increased significantly.

References

Stuart Warren, Organic Synthesis - The Disconnection Approach, page 180
http://webbook.nist.gov/chemistry/