It:PhenylButazone
PhenylButazone
Medical applications
Phenylbutazone has been used to treat serious pain in dogs due to osteoarthritis as it is a fast effective painkiller and also an anti-inflammatory. However dogs receiving intensive phenylbutazone therapy to tolerate the pain of osteoarthritis usually have regular blood work and renal monitoring to accompany this treatment. This is because an overdose of this drug is known to cause renal failure and liver injury. This drug is also used to treat horses for such problems as musculoskeletal problems, soft tissue injury and bone and joint problems. Phenylbutazone is a nonsterodial drug which provides fast acting pain relief one to two hours after initial introduction into the body. The drug can be taken either orally or intravenously to the blood.
Safety
This drug is harmful of swallowed in excess of the dosage prescribed, it is also irritating to both the skin and eyes and respiratory system. Another precaution when dealing with phenylbutazone is that it should not be given to animals that are pregnant or nursing young as research has indicated it’s harmful to embryos and young. This drug must not be injected into the muscles directly or under the skin.
Structure
| Structure of phenylbutazone | ||||
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| IR Spectrum of Phenylbutazone | ||||
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| Systematic Name | 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione | |||
| Alternative Chemical Names | Phenylbutazone | |||
| Molecular formula | C19H20N2O2 | |||
| Molecular Weight | 308.38 | |||
| Melting Points | 104-107 | |||
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References
http://jpet.aspetjournals.org/cgi/reprint/266/1/81.pdf
www.chemexper.com/
http://www.wedgewoodpharmacy.com/monographs/phenylbutazone.asp
http://www.sciencemag.org/cgi/content/abstract/159/3822/1479