It:Carboplatin

General

Systematic name

cis-Diamine[1,1-cyclobutanedicarboxylate]platinum

Molecular formula

C6H12N2O4Pt

Molar mass

371.21g/mol

Appearance

Solid

CAS number

41575-94-4

Main hazards

? Hazardous in case of skin contanct (irratant permeator), of eye contanct (irratant),of ingestion, of inhalation (lung irratant)

NFPA 704

RTECS number

TP2300000

Introduction

One of the major cause of death in the world is cancer. So large amount of reserch an capital have been put into this field of chemistry to improve the treatment of cancer in the medical field. A very famous anticancer drug used is the cisplatin(cis-diaminedichloro platinum). In 1696 an American scientist Rosenberg proved its effect in animals since it is widely used drug to combat the disease. However side effects of cisplatin can be quite unpleasent(nausea,kidney poisoning). This is caused by the fact that this chemical inhibits cancer cell DNA synthesis but ath the same time, it inhibits healthy cells' growth too. Especially the latter is considered to be quite serius and improvement had to be made for cases where usage of cisplatin was not desired. Then carbopltain was introdused.

Uses

Carboplatin is an alkylating agent used to treat ovarian and lung cancer. Its mechanism is unclear but it is likely that it inhibits the cancer cell DNA synthesis. Carboplatin is less toxic than cisplatin but it like cisplatin it can inhibit the growth of the healthy cells.

Anaphylaxis Reaction

There are very few reports of anaphylaxis reaction towards carboplatin, it is becoming more likely that it can in fact cause a shock. Some research claims that overdose of this drug can make the patients bodly system very sensitive to this drug which may result in a shock. Especially it is though to be very dengerous to use this drug during suegry.

Reference

http://www.jstage.jst.go.jp/article/jjsca/25/1/25_18/_article/-char/ja