It07:Gentamycin
Gentamycin A
Gentamycin is an aminoglycoside antibiotic, which can be used to treat several bacterial infections, especially those of the gram-negative variety.
It cannot be taken orally in order for it to work effectively, and so must be taken intravenously, intramuscularly or topically. Its benefits are used to help treat bacterial infections such as Pseudomonas, Proteus, Serratia, and gram-positive Staphylococcus.
Unwanted side effects of taking Gentamycin include possible kidney function problems, as it is nephrotoxic, and also hearing problems due to general aminoglycosides being toxic to the sensory cells of the ear.
| Gentamycin A | |
|---|---|
| |
| IUPAC Systematic name | |
| 2-[4,6-diamino-3- [3-amino-6-(1-methylaminoethyl) tetrahydropyran-2-yl] oxy-2-hydroxy- cyclohexoxy]-5-methyl- 4-methylamino-tetrahydropyran-3,5-diol | |
| Other name | |
| Gentamicin | |
| Indentifiers | |
| ATC Code | D06AX07 J01GB03, S01AA11, S02AA14, S03AA16 |
| CAS number | 1403-66-3 |
| PubChem (CID) | 3467 |
| SMILES | [H)C)1O CC(C(C(O)C(OC2C(C(OC3OC(C(NC)C)CCC3N)C(N)CC2N)O)OC1)N([H])C)1O] |
| Chemical Data | |
| Molecular formula | C21H43N5O7 |
| Molar mass | 477.596 g/mol g/mol |
| Pharmacokinetic Data | |
| Bioavailability | Limited oral bioavailability |
| Protein Binding | 0-10% |
| Metabolism | |
| Half life | 2 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | IV/IM |