It07:Amoxicillin
| Amoxicillin | |
|---|---|
| |
| |
| IUPAC Systematic name | |
| 7-[2-amino-2-(4-hydroxyphenyl) -acetyl]amino-3,3-dimethyl-6-oxo -2-thia-5-azabicyclo[3.2.0]heptane -4-carboxylic acid | |
| Indentifiers | |
| ATC Code | J01CA04 |
| CAS number | 26787-78-0 |
| PubChem (CID) | Substance: 175459
Compound: 33613 |
| SMILES | OC1=CC=C([C@H](C(N[C@@H]2C(N([C@@H]([C@](O)=O)C(C)(C)S3)[C@]32[H])=O)=O)N)C=C1 |
| Chemical Data | |
| Molecular formula | C16H19N3O5S |
| Molar mass | 365.4 g/mol |
| Pharmacokinetic Data | |
| Bioavailability | 95% oral |
| Protein Binding | Approximately 20% protein-bound in blood serum |
| Metabolism | Less than 30% biotransformed in liver |
| Half life | 61.3 minutes |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | A(AU) B(US) |
| Legal status | POM(UK) |
| Routes | Oral, intravenous |
Amoxicillin, (also called amoxicillin) is an antibiotic in the penicillin group. It is used to treat a variety of infections bacteria. The oral route of taking amoxicillin and the easily absorbed character makes it a better choice than other antibiotics in beta-lactam antibiotics.
Jmol 3D structural views of molecule:
Indications & Dosage
Amoxicillin can be used to treat infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).#[1]
Amoxicillin can be taken as Capsule (250 mg or 500 mg), Powder for solution, Powder for suspension, Suspension and Tablet (500 mg or 875 mg). Capsules and tablets should be taken with a glass of water. The usual dosage for adult is 500 mg every 12 hours or 250 mg every 8 hours for ear, nose or throat infection. For a severe infection, the dosage will be 875 mg every 12 hours or 500 mg every 8 hours. It can be taken with or without meals.
Side effect
Serious toxicity may not occur after taking large dose of Amoxicillin. However, nausea, vomiting or diarrhea may occur.