ChemWiki - User contributions [en]

It07:Rivaroxaban

2007-11-15T14:41:47Z

Sl1006: /* Clinical Trials */

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

== Mode of action ==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.
[[Image:Coagulation.jpg]]

== Clinical Trials ==
Extensive testing of Rivaroxaban against existing drugs seem to indicate that Rivaroxaban has a few advantages over current medication. Tests conducted using Rivaroxaban have been primarily related to its effectiveness against venous thromboembolism (VTE). Over 40,000 patients have been tested. Test results have shown that it has similar efficacy to the existing drug enoxaparin in prevention of VTE in patients undergoing knee replacement surgery. Other results have shown that the drug has predictable coagulation patterns, meaning that constant monitoring of dosage is not necessary- an advantage over using alternative drugs such as warfarin. Furthermore, it is an oral drug, dispensing the need for drug administration via injection (enoxaparin has to be administered in this way). Also, studies show that Rivaroxaban doesn’t interact with other drugs given in conjunction with anticoagulants.

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
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<size>200</size>
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<item><text>Stop spinning</text><script>spin off</script></item>
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<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

It07:Rivaroxaban

2007-11-15T14:38:06Z

Sl1006: added 3d of molecule

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

== Mode of action ==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.
[[Image:Coagulation.jpg]]

== Clinical Trials ==
Extensive testing of Rivaroxaban against existing drugs seem to indicate that Rivaroxaban has a few advantages over current medication. Tests conducted using Rivaroxaban have been primarily related to its effectiveness against venous thromboembolism (VTE). Over 40,000 patients have been tested. Test results have shown that it has similar efficacy to the existing drug enoxaparin in prevention of VTE in patients undergoing knee replacement surgery. Other results have shown that the drug has predictable coagulation patterns, meaning that constant monitoring of dosage is not necessary- an advantage over using alternative drugs such as warfarin. Furthermore, it is an oral drug, dispensing the need for drug administration via injection (enoxaparin has to be administered in this way). Also, studies show that Rivaroxaban doesn’t interact with other drugs given in conjunction with anticoagulants.

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
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<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
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<jmolButton>
<script>console</script>
<text>open a console window</text>
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<jmol>
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<size>200</size>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
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<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

It07:Rivaroxaban

2007-11-05T16:41:29Z

Sl1006:

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

== Mode of action ==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.
[[Image:Coagulation.jpg]]

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
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<jmolMenu>
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<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
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<jmolButton>
<script>console</script>
<text>open a console window</text>
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<jmol>
<jmolAppletButton>
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<color>cyan</color>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
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File:Coagulation.jpg

2007-11-05T16:38:20Z

Sl1006:

It07:Rivaroxaban

2007-11-05T16:32:21Z

Sl1006: /* Rivaroxaban */

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

== Mode of action ==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

<jmol>
<jmolAppletButton>
<title>Show Pentahelicene in popup window</title>
<color>cyan</color>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolAppletButton>

It07:Rivaroxaban

2007-11-05T16:31:30Z

Sl1006:

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

<jmol>
<jmolAppletButton>
<title>Show Pentahelicene in popup window</title>
<color>cyan</color>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolAppletButton>

== Mode of action ==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.

It07:Rivaroxaban

2007-11-05T16:30:59Z

Sl1006: /* Rivaroxaban */

== Rivaroxaban ==
Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade. Although still under development by Bayer, test results suggest that Rivaroxaban is more effective than current medication in use.

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:Rivaroxthing.jpg|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| 5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

|-
| Other names
| Xarelto, BAY-59-7939
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| C<sub>19</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>5</sub>S

|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| 435.88132 g/mol
|-
| Appearance
|
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| 366789-02-8
|-
| Chemfinder ACX number
|
|-
| [http://en.wikipedia.org/wiki/SMILES SMILES]
| ClC1=CC=C(C(NCC(CN2C3=CC=C(N(CCOC4)C4=O)C=C3)OC2=O)=O)S1
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
|
|-
|Vapour Pressure
|
|-
| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
|
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
|
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
|
|-
| [http://en.wikipedia.org/wiki/Dipole#Molecular_dipoles Dipole moment]
| [http://en.wikipedia.org/wiki/Debye D]
|-
! {{chembox header}} | Hazards 
|-
| Main Hazards
|
|-
| [http://en.wikipedia.org/wiki/NFPA_704 NFPA 704]
|
|-
| [[Flash point]]
| N/A
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Rivaroxban3d.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

<jmol>
<jmolAppletButton>
<title>Show Pentahelicene in popup window</title>
<color>cyan</color>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolAppletButton>

==Mode of action==
Rivaroxaban targets the active site of Factor Xa. Factor Xa is central in the coagulation cascade, connecting the intrinsic and extrinsic pathways. Factor Xa cleaves prothrombin to thrombin, which in turn catalyses the formation of fibrinogen to fibrin and thereby forming blood clots. Factor Xa is the only enzyme capable of cleaving prothrombin, thus blocking its action will undoubtedly stop blood clotting.

It07:Bisacodyl

2007-10-25T16:14:09Z

Sl1006: /* Bisacodyl */

== Bisacodyl ==
</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:{{PAGENAME}}.jpg|200px|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| [4-[(4-acetyloxyphenyl)-pyridin-2-yl-methyl]phenyl] acetate
|-
| Other names
| {{{OtherNames}}}
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| {{{Formula}}}
|-
| [http://en.wikipedia.org/wiki/Chemical_file_format SMILES] 
| {{{SMILES}}}
|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| {{{MolarMass}}}
|-
| Appearance
| {{{Appearance}}}
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| {{{CASNo}}}
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Density Density] & [http://en.wikipedia.org/wiki/Phase_%28matter%29 phase]
| {{{Density}}} g/cm³ 
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
| {{{Sol_Water}}} g/100 ml (25°C) 
|-



| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| {{{Mp}}} K 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
| {{{Bp}}} K
|-
| [http://en.wikipedia.org/wiki/Acid_dissociation_constant Acidity] (p''K''<sub>a</sub>) 
| {{{pKa}}}
|-
| [http://en.wikipedia.org/wiki/Acid_dissociation_constant Basicity] (p''K''<sub>b</sub>) 
| {{{pKb}}}
|-
| [http://en.wikipedia.org/wiki/Specific_rotation Chiral rotation <nowiki>[α]</nowiki><sub>D</sub>] 
| {{{Rotation}}}°
|-
| [http://en.wikipedia.org/wiki/Viscosity Viscosity]
| {{{Viscosity}}} [[Poise|cP]] at 25°C 
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
| {{{Mol_Shape}}} 
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
| {{{Coordination}}} 
|-
| [http://en.wikipedia.org/wiki/Crystal_structure Crystal structure] 
| {{{Crystal_Structure}}} 
|-
| [[Dipole#Molecular_dipoles|Dipole moment]]
| {{{DM}}} [[Debye|D]]
|-
! {{chembox header}} | Hazards 
|-
| [[Material safety data sheet|MSDS]]
| [[{{PAGENAME}} (data page)#Material Safety Data Sheet|External MSDS]] 
|-
| Main [[Worker safety and health|hazard]]s
| {{{Hazards}}} 
|-
| [[NFPA 704]]
| {{{NFPA}}}
|-
| [[Flash point]]
| {{{Fp}}}°C
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

It:projects

2007-10-25T16:10:54Z

Sl1006: /* Supplemental Project Page */

__FORCETOC__

'''''You MUST use the Edit buttons on the right to edit this content. Do NOT use the Edit button on the top of this page.'''''
== Sandbox (Play-Pen) ==

This is an area where you can play without worrying what you do. Enter it by pressing the [Edit] button '''on the right''' and '''not''' at the top. Go here for a [http://en.wikipedia.org/wiki/Wikipedia:Cheatsheet ''cheat sheet''] summary of how to create a Wiki page. It's a free-for-all in here! Learn how to use a Wiki by coming here! PS This is how to do Greek:α, β Δ, δ
Try copying/pasting some of the [http://www.ch.ic.ac.uk/local/it/lab1.html examples in the course work] into this page. See the effect by selecting '''Show Preview'''. Do not use '''Save Page''' so as to leave this area uncluttered for others.
----
{| summary="CIT Project Titles" border="1"
|NEW: This demonstrates the use of Jmol loading discrete molecule files (rather than having to paste them into the wiki page). Upload the molecule file, and invoke it as shown here. Use it for eg loading large proteins etc.--[[User:Rzepa|Rzepa]] 16:07, 4 December 2006 (UTC) and --[[User:Rzepa|Rzepa]] 07:41, 16 October 2007 (BST) and --[[User:Rzepa|Rzepa]] 15:56, 18 October 2007 (BST)

If no rotatable molecule appears to the right, test that [http://www.java.com/en/download/help/testvm.xml Java] is correctly functioning on your system.

===References ===
This shows how citations<ref>Example of adding a citation {{DOI|10.1021/ja9825332}}</ref> can be added to
text<ref>adding a further citation {{DOI|10.1021/ja9825332}}</ref> to produce a nice effect.

=== Collected citations appear below here ===
<references />--[[User:Rzepa|Rzepa]] 15:18, 25 October 2007 (BST)
|<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color><size>200</size>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>
<jmol><jmolAppletButton><title>Show CIYSIM.cif in popup window</title><color>cyan</color>
<uploadedFileContents>CIYSIM.cif</uploadedFileContents></jmolAppletButton>
</jmol>
|}

== Main Project Page ==
'''Please do not edit this page itself'''. Click on one of the titles to start editing.
{| summary="CIT Project Titles" border="1"
! bgcolor="cyan" |Project<br /> Number
! bgcolor="cyan" |General Keywords
|-
| bgcolor="#CCFF00" |01
| bgcolor="#CCFF00" | [[it07:Lignocaine|Lignocaine (used in dentistry as a "local")]]
|-
| bgcolor="#CCFF00" |02
| bgcolor="#66FF99" | [[it07:Piperine|Piperine (active ingredient of both black and white pepper)]]
|-
| bgcolor="#CCFF00" |03
| bgcolor="#CCFF00" | [[it07:Rapamycin|Rapamycin (prevents transplant rejection)]]
|-
| bgcolor="#CCFF00" |04
| bgcolor="#66FF99" | [[it07:Gossypol|Gossypol (male birth control)]]
|-
| bgcolor="#CCFF00" |05
| bgcolor="#CCFF00" | [[it07:Gentamycin|Gentamicin A (aminoglycoside antibiotic)]]
|-
| bgcolor="#CCFF00" |06
| bgcolor="#66FF99" | [[it07:Herceptin|Herceptin (topical anticancer drug)]]
|-
| bgcolor="#CCFF00" |07
| bgcolor="#CCFF00" | [[it07:Gingerone|Zingerone (the characteristic smell of ginger)]]
|-
| bgcolor="#CCFF00" |08
| bgcolor="#66FF99" | [[it07:Sucralose|Sucralose (non-metabolizable sweetening agent)]]
|-
| bgcolor="#CCFF00" |09
| bgcolor="#CCFF00" | [[it07:Bufotoxin|Bufotoxin (active component of the toad ''Bufo vulgaris'')]]
|-
| bgcolor="#CCFF00" |10
| bgcolor="#66FF99" | [[it07:Roaccutane|Roaccutane (treatment for severe acne)]]
|-
| bgcolor="#CCFF00" |11
| bgcolor="#CCFF00" | [[it07:Sibutramine|Sibutramine (appetite suppresor)]]
|-
| bgcolor="#CCFF00" |12
| bgcolor="#66FF99" | [[it07:Anandamide|Anandamide (the "feel-good" factor in chocolate)]]
|-
| bgcolor="#CCFF00" |13
| bgcolor="#CCFF00" | [[it07:h3nbh3|Ammonia-borane: H<sub>3</sub>N-BH<sub>3</sub> (Hydrogen storage molecule?)]]
|-
| bgcolor="#CCFF00" |14
| bgcolor="#66FF99" | [[it07:Methoxsalen|Methoxsalen (Treatment of psoriasis)]]
|-
| bgcolor="#CCFF00" |15
| bgcolor="#CCFF00" | [[it07:Hycocine|Hyoscine (From Mandrake and Witches Henbane, pre-med before surgery)]]
|-
| bgcolor="#CCFF00" |16
| bgcolor="#66FF99" | [[it07:Capreomycin|Capreomycin (Drug-resistant TB)]]
|}

== Supplemental Project Page ==

This area is for people who wish to create their own projects if none of the above appeal to them. Click on the '''Edit''' button to the right to open up an editable page,
then add an entry below as follows

*<nowiki> [[it07:name_of_project|Descriptive name of intended project]]</nowiki>
*This will produce the effect: [[it07:name_of_project|Descriptive name of intended project]]
----
#[[it07:sitagliptin_page|An example entry- in edit mode, please copy this line and paste below to add to this list]]
#[[it07:name_of_project|Vitamin C ]]
#[[it07:Cylcophosphamide|Cyclophosphamide]]
#[[it07:Terbutaline Sulphate|Terbutaline Sulphate]]
#[[it07:Caffeine|Caffeine]]
#[[it07:Mefloquine|Mefloquine]]
#[[it07:Cadaverine|Cadaverine]]
#[[it07:Cyanidin|Cyanidin]]
#[[it07:Ezetimibe|Ezetimibe]]
#[[it07:Azadirachtin|Azadirachtin]]
#[[it07:Nicotine|Nicotine]]
#[[Image:chem.png]][[it07:Cyclopentasiloxane|Cyclopentasiloxane]]
#[[it07:Trinitrotoluene|Trinitrotoluene]]
#[[it07:Hydroxychloroquine|Hydroxychloroquine]]
#[[Aspartame|Aspartame]]
#[[it07:Azulene|Azulene]]
#[[it07:Chlorine Trifluoride|Chlorine Trifluoride]]
#[[it07:Cholesterol|Cholesterol]]
#[[it07:Vitamin E|Vitamin E]]
#[[it07:Phenothiazine|Phenothiazine]]
#[[it07:linalool|linalool]]
#[[it07:Glutamic acid|Glutamic acid]]
#[[it07:N-(4-hydroxyphenyl)ethanamide|N-(4-hydroxyphenyl)ethanamide]]
#[[it07:Epinephrine|Epinephrine]]
#[[it07:Sodium Valproate|Sodium Valproate]]
#[[it07:Hyaluronic acid |Hyaluronic acid ]]
#[[it07:Methylenedioxymethamphetamine |Methylenedioxymethamphetamine ]]
#[[it07:salicylic acid |salicylic acid ]]
#[[it07:Morphine|Morphine]]
#[[Cetirizine]]
#[[it07:Bisacodyl|Bisacodyl]]
#[[it07:Rivaroxaban|Rivaroxaban]]

== Cetirizine ==
Utilities have been written to help the conversion of material from HTML.
# [http://diberri.dyndns.org/wikipedia/html2wiki/ A HTML2Wiki Converter]
----

== Wiki Templates ==

[[Template:DOI]] and [[Template:Doi-inline]] are providea as (protected) templates for your use. Many other templates exist, often to be found on e.g. Wikipedia pages. You may decide one of these is of particular use, or of interest. If so, you can install it on the wiki here for you and others to use. Add below a line that looks like Template:Template-name, save, and click on the red text to create the new template. If you prefer the task of adding useful templates to that of adding information about molecules, then you will be given full credit for performing this valuable service for others! --Rzepa 14:41, 20 October 2006 (BST)

[[Template:Chem-Data]]

[[Template:Drug-Box]] - For pharmaceutical drugs just copy variable names and code generates tables

[[Template:Chembox supplement]] - to be linked to from the supplementary section of the table in the template above, for usage see [[Template_talk:chembox_supplement|here]]

[[Template:NFPA_704]] - for notes on how to use, see [[Template_talk:NFPA_704|here]]

[[R & S Phrases]]

[[Template:Chembox new]]

File:Rivaroxban3dsl.mol

2007-10-25T15:58:21Z

Sl1006:

It07:Rivaroxaban

2007-10-25T15:04:30Z

Sl1006:

It07:Rivaroxaban

2007-10-25T14:47:26Z

Sl1006: /* Rivaroxaban */

File:Rivaroxthing.jpg

2007-10-25T14:38:54Z

Sl1006:

It07:Rivaroxaban

2007-10-25T14:29:01Z

Sl1006: /* Rivaroxaban */

It07:Rivaroxaban

2007-10-25T14:20:48Z

Sl1006: /* Rivaroxaban */

It07:Rivaroxaban

2007-10-25T14:14:18Z

Sl1006: /* Rivaroxaban */

It:projects

2007-10-25T14:10:05Z

Sl1006: /* Supplemental Project Page */

__FORCETOC__

'''''You MUST use the Edit buttons on the right to edit this content. Do NOT use the Edit button on the top of this page.'''''
== Sandbox (Play-Pen) ==

This is an area where you can play without worrying what you do. Enter it by pressing the [Edit] button '''on the right''' and '''not''' at the top. Go here for a [http://en.wikipedia.org/wiki/Wikipedia:Cheatsheet ''cheat sheet''] summary of how to create a Wiki page. It's a free-for-all in here! Learn how to use a Wiki by coming here! PS This is how to do Greek:α, β Δ, δ
Try copying/pasting some of the [http://www.ch.ic.ac.uk/local/it/lab1.html examples in the course work] into this page. See the effect by selecting '''Show Preview'''. Do not use '''Save Page''' so as to leave this area uncluttered for others.
----
{| summary="CIT Project Titles" border="1"
|NEW: This demonstrates the use of Jmol loading discrete molecule files (rather than having to paste them into the wiki page). Upload the molecule file, and invoke it as shown here. Use it for eg loading large proteins etc.--[[User:Rzepa|Rzepa]] 16:07, 4 December 2006 (UTC) and --[[User:Rzepa|Rzepa]] 07:41, 16 October 2007 (BST) and --[[User:Rzepa|Rzepa]] 15:56, 18 October 2007 (BST)

If no rotatable molecule appears to the right, test that [http://www.java.com/en/download/help/testvm.xml Java] is correctly functioning on your system.

===References ===
This shows how citations<ref>Example of adding a citation {{DOI|10.1021/ja9825332}}</ref> can be added to
text<ref>adding a further citation {{DOI|10.1021/ja9825332}}</ref> to produce a nice effect.

=== Collected citations appear below here ===
<references />
|<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color><size>200</size>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>
<jmol><jmolAppletButton><title>Show CIYSIM.cif in popup window</title><color>cyan</color>
<uploadedFileContents>CIYSIM.cif</uploadedFileContents></jmolAppletButton>
</jmol>
|}

== Main Project Page ==
'''Please do not edit this page itself'''. Click on one of the titles to start editing.
{| summary="CIT Project Titles" border="1"
! bgcolor="cyan" |Project<br /> Number
! bgcolor="cyan" |General Keywords
|-
| bgcolor="#CCFF00" |01
| bgcolor="#CCFF00" | [[it07:Lignocaine|Lignocaine (used in dentistry as a "local")]]
|-
| bgcolor="#CCFF00" |02
| bgcolor="#66FF99" | [[it07:Piperine|Piperine (active ingredient of both black and white pepper)]]
|-
| bgcolor="#CCFF00" |03
| bgcolor="#CCFF00" | [[it07:Rapamycin|Rapamycin (prevents transplant rejection)]]
|-
| bgcolor="#CCFF00" |04
| bgcolor="#66FF99" | [[it07:Gossypol|Gossypol (male birth control)]]
|-
| bgcolor="#CCFF00" |05
| bgcolor="#CCFF00" | [[it07:Gentamycin|Gentamicin A (aminoglycoside antibiotic)]]
|-
| bgcolor="#CCFF00" |06
| bgcolor="#66FF99" | [[it07:Herceptin|Herceptin (topical anticancer drug)]]
|-
| bgcolor="#CCFF00" |07
| bgcolor="#CCFF00" | [[it07:Gingerone|Zingerone (the characteristic smell of ginger)]]
|-
| bgcolor="#CCFF00" |08
| bgcolor="#66FF99" | [[it07:Sucralose|Sucralose (non-metabolizable sweetening agent)]]
|-
| bgcolor="#CCFF00" |09
| bgcolor="#CCFF00" | [[it07:Bufotoxin|Bufotoxin (active component of the toad ''Bufo vulgaris'')]]
|-
| bgcolor="#CCFF00" |10
| bgcolor="#66FF99" | [[it07:Roaccutane|Roaccutane (treatment for severe acne)]]
|-
| bgcolor="#CCFF00" |11
| bgcolor="#CCFF00" | [[it07:Sibutramine|Sibutramine (appetite suppresor)]]
|-
| bgcolor="#CCFF00" |12
| bgcolor="#66FF99" | [[it07:Anandamide|Anandamide (the "feel-good" factor in chocolate)]]
|-
| bgcolor="#CCFF00" |13
| bgcolor="#CCFF00" | [[it07:h3nbh3|Ammonia-borane: H<sub>3</sub>N-BH<sub>3</sub> (Hydrogen storage molecule?)]]
|-
| bgcolor="#CCFF00" |14
| bgcolor="#66FF99" | [[it07:Methoxsalen|Methoxsalen (Treatment of psoriasis)]]
|-
| bgcolor="#CCFF00" |15
| bgcolor="#CCFF00" | [[it07:Hycocine|Hyoscine (From Mandrake and Witches Henbane, pre-med before surgery)]]
|-
| bgcolor="#CCFF00" |16
| bgcolor="#66FF99" | [[it07:Capreomycin|Capreomycin (Drug-resistant TB)]]
|}

== Supplemental Project Page ==

This area is for people who wish to create their own projects if none of the above appeal to them. Click on the '''Edit''' button to the right to open up an editable page,
then add an entry below as follows

*<nowiki> [[it07:name_of_project|Descriptive name of intended project]]</nowiki>
*This will produce the effect: [[it07:name_of_project|Descriptive name of intended project]]
----
#[[it07:sitagliptin_page|An example entry- in edit mode, please copy this line and paste below to add to this list]]
#[[it07:name_of_project|Vitamin C ]]
#[[it07:Cylcophosphamide|Cyclophosphamide]]
#[[it07:Terbutaline Sulphate|Terbutaline Sulphate]]
#[[it07:Caffeine|Caffeine]]
#[[it07:Mefloquine|Mefloquine]]
#[[it07:Cadaverine|Cadaverine]]
#[[it07:Cyanidin|Cyanidin]]
#[[it07:Ezetimibe|Ezetimibe]]
#[[it07:Azadirachtin|Azadirachtin]]
#[[it07:Nicotine|Nicotine]]
#[[Image:chem.png]][[it07:Cyclopentasiloxane|Cyclopentasiloxane]]
#[[it07:Trinitrotoluene|Trinitrotoluene]]
#[[it07:Hydroxychloroquine|Hydroxychloroquine]]
#[[Aspartame|Aspartame]]
#[[it07:Azulene|Azulene]]
#[[it07:Chlorine Trifluoride|Chlorine Trifluoride]]
#[[it07:Cholesterol|Cholesterol]]
#[[it07:Vitamin E|Vitamin E]]
#[[it07:Phenothiazine|Phenothiazine]]
#[[it07:linalool|linalool]]
#[[it07:Glutamic acid|Glutamic acid]]
#[[it07:N-(4-hydroxyphenyl)ethanamide|N-(4-hydroxyphenyl)ethanamide]]
#[[it07:Epinephrine|Epinephrine]]
#[[it07:Sodium Valproate|Sodium Valproate]]
#[[it07:Hyaluronic acid |Hyaluronic acid ]]
#[[it07:Methylenedioxymethamphetamine |Methylenedioxymethamphetamine ]]
#[[it07:salicylic acid |salicylic acid ]]
#[[it07:Morphine |Morphine ]]
#[[Cetirizine]]
#[[it07:Rivaroxaban|Rivaroxaban]]

== Cetirizine ==
Utilities have been written to help the conversion of material from HTML.
# [http://diberri.dyndns.org/wikipedia/html2wiki/ A HTML2Wiki Converter]
----

== Wiki Templates ==

[[Template:DOI]] and [[Template:Doi-inline]] are providea as (protected) templates for your use. Many other templates exist, often to be found on e.g. Wikipedia pages. You may decide one of these is of particular use, or of interest. If so, you can install it on the wiki here for you and others to use. Add below a line that looks like Template:Template-name, save, and click on the red text to create the new template. If you prefer the task of adding useful templates to that of adding information about molecules, then you will be given full credit for performing this valuable service for others! --Rzepa 14:41, 20 October 2006 (BST)

[[Template:Chem-Data]]

[[Template:Drug-Box]] - For pharmaceutical drugs just copy variable names and code generates tables

[[Template:Chembox supplement]] - to be linked to from the supplementary section of the table in the template above, for usage see [[Template_talk:chembox_supplement|here]]

[[Template:NFPA_704]] - for notes on how to use, see [[Template_talk:NFPA_704|here]]

[[R & S Phrases]]

[[Template:Chembox new]]

It07:Rivaroxaban

2007-10-25T14:03:43Z

Sl1006: New page: == Rivaroxaban == Rivaroxaban, or Xarelto, is a drug used to prevent or treat blood clots (it is an anti- coagulant) by inhibition of Factor Xa- an enzyme found in the coagulation cascade....

It:projects

2007-10-25T14:02:22Z

Sl1006: /* Supplemental Project Page */

__FORCETOC__

'''''You MUST use the Edit buttons on the right to edit this content. Do NOT use the Edit button on the top of this page.'''''
== Sandbox (Play-Pen) ==

This is an area where you can play without worrying what you do. Enter it by pressing the [Edit] button '''on the right''' and '''not''' at the top. Go here for a [http://en.wikipedia.org/wiki/Wikipedia:Cheatsheet ''cheat sheet''] summary of how to create a Wiki page. It's a free-for-all in here! Learn how to use a Wiki by coming here! PS This is how to do Greek:α, β Δ, δ
Try copying/pasting some of the [http://www.ch.ic.ac.uk/local/it/lab1.html examples in the course work] into this page. See the effect by selecting '''Show Preview'''. Do not use '''Save Page''' so as to leave this area uncluttered for others.
----
{| summary="CIT Project Titles" border="1"
|NEW: This demonstrates the use of Jmol loading discrete molecule files (rather than having to paste them into the wiki page). Upload the molecule file, and invoke it as shown here. Use it for eg loading large proteins etc.--[[User:Rzepa|Rzepa]] 16:07, 4 December 2006 (UTC) and --[[User:Rzepa|Rzepa]] 07:41, 16 October 2007 (BST) and --[[User:Rzepa|Rzepa]] 15:56, 18 October 2007 (BST)

If no rotatable molecule appears to the right, test that [http://www.java.com/en/download/help/testvm.xml Java] is correctly functioning on your system.

|<jmol>
<jmolApplet>
<title>Pentahelicene</title><color>yellow</color><size>200</size>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolApplet>
<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>
<jmol><jmolAppletButton><title>Show CIYSIM.cif in popup window</title><color>cyan</color>
<uploadedFileContents>CIYSIM.cif</uploadedFileContents></jmolAppletButton>
</jmol>
|}

== Main Project Page ==
'''Please do not edit this page itself'''. Click on one of the titles to start editing.
{| summary="CIT Project Titles" border="1"
! bgcolor="cyan" |Project<br /> Number
! bgcolor="cyan" |General Keywords
|-
| bgcolor="#CCFF00" |01
| bgcolor="#CCFF00" | [[it07:Lignocaine|Lignocaine (used in dentistry as a "local")]]
|-
| bgcolor="#CCFF00" |02
| bgcolor="#66FF99" | [[it07:Piperine|Piperine (active ingredient of both black and white pepper)]]
|-
| bgcolor="#CCFF00" |03
| bgcolor="#CCFF00" | [[it07:Rapamycin|Rapamycin (prevents transplant rejection)]]
|-
| bgcolor="#CCFF00" |04
| bgcolor="#66FF99" | [[it07:Gossypol|Gossypol (male birth control)]]
|-
| bgcolor="#CCFF00" |05
| bgcolor="#CCFF00" | [[it07:Gentamycin|Gentamicin A (aminoglycoside antibiotic)]]
|-
| bgcolor="#CCFF00" |06
| bgcolor="#66FF99" | [[it07:Herceptin|Herceptin (topical anticancer drug)]]
|-
| bgcolor="#CCFF00" |07
| bgcolor="#CCFF00" | [[it07:Gingerone|Zingerone (the characteristic smell of ginger)]]
|-
| bgcolor="#CCFF00" |08
| bgcolor="#66FF99" | [[it07:Sucralose|Sucralose (non-metabolizable sweetening agent)]]
|-
| bgcolor="#CCFF00" |09
| bgcolor="#CCFF00" | [[it07:Bufotoxin|Bufotoxin (active component of the toad ''Bufo vulgaris'')]]
|-
| bgcolor="#CCFF00" |10
| bgcolor="#66FF99" | [[it07:Roaccutane|Roaccutane (treatment for severe acne)]]
|-
| bgcolor="#CCFF00" |11
| bgcolor="#CCFF00" | [[it07:Sibutramine|Sibutramine (appetite suppresor)]]
|-
| bgcolor="#CCFF00" |12
| bgcolor="#66FF99" | [[it07:Anandamide|Anandamide (the "feel-good" factor in chocolate)]]
|-
| bgcolor="#CCFF00" |13
| bgcolor="#CCFF00" | [[it07:h3nbh3|Ammonia-borane: H<sub>3</sub>N-BH<sub>3</sub> (Hydrogen storage molecule?)]]
|-
| bgcolor="#CCFF00" |14
| bgcolor="#66FF99" | [[it07:Methoxsalen|Methoxsalen (Treatment of psoriasis)]]
|-
| bgcolor="#CCFF00" |15
| bgcolor="#CCFF00" | [[it07:Hycocine|Hyoscine (From Mandrake and Witches Henbane, pre-med before surgery)]]
|-
| bgcolor="#CCFF00" |16
| bgcolor="#66FF99" | [[it07:Capreomycin|Capreomycin (Drug-resistant TB)]]
|}

== Supplemental Project Page ==

This area is for people who wish to create their own projects if none of the above appeal to them. Click on the '''Edit''' button to the right to open up an editable page,
then add an entry below as follows

*<nowiki> [[it07:name_of_project|Descriptive name of intended project]]</nowiki>
*This will produce the effect: [[it07:name_of_project|Descriptive name of intended project]]
----
#[[it07:sitagliptin_page|An example entry- in edit mode, please copy this line and paste below to add to this list]]
#[[it07:name_of_project|Vitamin C ]]
#[[it07:Cylcophosphamide|Cyclophosphamide]]
#[[it07:Terbutaline Sulphate|Terbutaline Sulphate]]
#[[it07:Caffeine|Caffeine]]
#[[it07:Mefloquine|Mefloquine]]
#[[it07:Cadaverine|Cadaverine]]
#[[it07:Cyanidin|Cyanidin]]
#[[it07:Ezetimibe|Ezetimibe]]
#[[it07:Azadirachtin|Azadirachtin]]
#[[it07:Nicotine|Nicotine]]
#[[Image:chem.png]][[it07:Cyclopentasiloxane|Cyclopentasiloxane]]
#[[it07:Trinitrotoluene|Trinitrotoluene]]
#[[it07:Hydroxychloroquine|Hydroxychloroquine]]
#[[Aspartame|Aspartame]]
#[[it07:Azulene|Azulene]]
#[[it07:Chlorine Trifluoride|Chlorine Trifluoride]]
#[[it07:Cholesterol|Cholesterol]]
#[[it07:Vitamin E|Vitamin E]]
#[[it07:Phenothiazine|Phenothiazine]]
#[[it07:linalool|linalool]]
#[[it07:Glutamic acid|Glutamic acid]]
#[[it07:N-(4-hydroxyphenyl)ethanamide|N-(4-hydroxyphenyl)ethanamide]]
#[[it07:Epinephrine|Epinephrine]]
#[[it07:Sodium Valproate|Sodium Valproate]]
#[[it07:Hyaluronic acid |Hyaluronic acid ]]
#[[it07:Methylenedioxymethamphetamine |Methylenedioxymethamphetamine ]]
#[[it07:salicylic acid |salicylic acid ]]
#[[it07:Morphine |Morphine ]]
#[[it07:Rivaroxaban|Rivaroxaban ]]

== Wiki Utillities ==
Utilities have been written to help the conversion of material from HTML.
# [http://diberri.dyndns.org/wikipedia/html2wiki/ A HTML2Wiki Converter]
----

== Wiki Templates ==

[[Template:DOI]] and [[Template:Doi-inline]] are providea as (protected) templates for your use. Many other templates exist, often to be found on e.g. Wikipedia pages. You may decide one of these is of particular use, or of interest. If so, you can install it on the wiki here for you and others to use. Add below a line that looks like Template:Template-name, save, and click on the red text to create the new template. If you prefer the task of adding useful templates to that of adding information about molecules, then you will be given full credit for performing this valuable service for others! --Rzepa 14:41, 20 October 2006 (BST)

[[Template:Chem-Data]]

[[Template:Drug-Box]] - For pharmaceutical drugs just copy variable names and code generates tables

[[Template:Chembox supplement]] - to be linked to from the supplementary section of the table in the template above, for usage see [[Template_talk:chembox_supplement|here]]

[[Template:NFPA_704]] - for notes on how to use, see [[Template_talk:NFPA_704|here]]

[[R & S Phrases]]

[[Template:Chembox new]]

It07:Cadaverine

2007-10-22T14:30:22Z

Sl1006: /* Cadaverine (Pentane 1,5 diamine) */

== Cadaverine (Pentane 1,5 diamine) ==
'''Cadaverine''' is a diamine better known for its putrid smell in human corpses. It is produced naturally by putrefaction, but it can also be synthesised.
<jmol>
<jmolApplet>
<title>cadaverine.PDB</title><color>yellow</color>
<size>200</size>
<script>zoom 80; cpk -25;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<uploadedFileContents>cadaverine.PDB</uploadedFileContents>
</jmolApplet>

<jmolMenu>
<item><text>Start spinning</text><script>spin on</script></item>
<item><text>Stop spinning</text><script>spin off</script></item>
<menuHeight>-1</menuHeight>
</jmolMenu>
<jmolButton>
<script>console</script>
<text>open a console window</text>
</jmolButton>
</jmol>

<jmol>
<jmolAppletButton>
<title>Show Pentahelicene in popup window</title>
<color>cyan</color>
<uploadedFileContents>Pentahelicene.mol</uploadedFileContents>
</jmolAppletButton>
</jmol>

<noinclude>

</noinclude>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse; width: 280px"
! {{chembox header}} | {{PAGENAME}} 
|-
| align="center" colspan="2" bgcolor="#ffffff" | [[Image:{{PAGENAME}}.jpg|200px|{{PAGENAME}}]] 
|-
! {{chembox header}} | General
|-
| [http://en.wikipedia.org/wiki/IUPAC Systematic name]
| {{{Pentane 1,5 diamine}}}

|-
| Other names
| {{{Cadaverine}}}
|-
| [http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]
| {{{C5H14N2}}}
|-
| [http://en.wikipedia.org/wiki/Chemical_file_format SMILES] 
| {{{NCCCCCN}}}
|-
| [http://en.wikipedia.org/wiki/Molar_mass Molar mass]
| {{{102.18}}}
|-
| Appearance
| {{{Appearance}}}
|-
| [http://en.wikipedia.org/wiki/CAS_registry_number CAS number]
| {{{462-94-2}}}
|-
! {{chembox header}} | Properties
|-
| [http://en.wikipedia.org/wiki/Density Density] & [http://en.wikipedia.org/wiki/Phase_%28matter%29 phase]
| {{{0.873 g/mL at 25 °C(lit.)}}} g/cm³ 
|-
| [http://en.wikipedia.org/wiki/Solubility Solubility in water]
| {{{Sol_Water}}} g/100 ml (25°C) 
|-



| [http://en.wikipedia.org/wiki/Melting_point Melting point]
| {{{14-16 °C(lit.)}}} K 
|-
| [http://en.wikipedia.org/wiki/Boiling_point Boiling point]
| {{{178-180 °C(lit.)}}} K
|-
| [http://en.wikipedia.org/wiki/Acid_dissociation_constant Acidity] (p''K''<sub>a</sub>) 
| {{{pKa}}}
|-
| [http://en.wikipedia.org/wiki/Acid_dissociation_constant Basicity] (p''K''<sub>b</sub>) 
| {{{pKb}}}
|-
| [http://en.wikipedia.org/wiki/Specific_rotation Chiral rotation <nowiki>[α]</nowiki><sub>D</sub>] 
| {{{Rotation}}}°
|-
| [http://en.wikipedia.org/wiki/Viscosity Viscosity]
| {{{Viscosity}}} [[Poise|cP]] at 25°C 
|-
! {{chembox header}} | Structure
|-
| [http://en.wikipedia.org/wiki/Orbital_hybridisation Molecular shape] 
| {{{Mol_Shape}}} 
|-
| [http://en.wikipedia.org/wiki/Coordination_geometry Coordination<br />geometry] 
| {{{Coordination}}} 
|-
| [http://en.wikipedia.org/wiki/Crystal_structure Crystal structure] 
| {{{Crystal_Structure}}} 
|-
| [[Dipole#Molecular_dipoles|Dipole moment]]
| {{{DM}}} [[Debye|D]]
|-
! {{chembox header}} | Hazards 
|-
| [[Material safety data sheet|MSDS]]
| [[{{PAGENAME}} (data page)#Material Safety Data Sheet|External MSDS]] 
|-
| Main [[Worker safety and health|hazard]]s
| {{{Hazards}}} 
|-
| [[NFPA 704]]
| {{{NFPA}}}
|-
| [[Flash point]]
| {{{Fp}}}°C
|-
| [[Risk and Safety Statements|R/S statement]]
| [[List of R-phrases|R]]: {{{R-S}}} <br /> [[List of S-phrases|S]]: ?
|-
| [[RTECS]] number
| {{{RTECS}}}
|-
! {{chembox header}} | [[{{PAGENAME}} (data page)|Supplementary data page]]
|-
| [[{{PAGENAME}} (data page)#Structure and properties|Structure and<br />properties]]
| [http://en.wikipedia.org/wiki/Refractive_index ''n''], [http://en.wikipedia.org/wiki/Dielectric_constant ε<sub>r</sub>], etc.
|-
| [[{{PAGENAME}} (data page)#Thermodynamic properties|Thermodynamic<br />data]]
| Phase behaviour<br />Solid, liquid, gas
|-
| [[{{PAGENAME}} (data page)#Spectral data|Spectral data]]
| [[UV/VIS spectroscopy|UV]], [[Infrared spectroscopy|IR]], [[nuclear magnetic resonance spectroscopy|NMR]], [[Mass spectrometry|MS]]
|-
! {{chembox header}} | Related compounds
|-
| Other [[Ion|anion]]s 
| {{{Other_anion}}} 
|-
| Other [[Ion|cation]]s 
| {{{Ohter_cation}}} 
|-
| Related compounds

| {{{Relative_Compounds}}}
|-
| {{chembox header}} | <small>Except where noted otherwise, data are given for<br /> materials in their [[standard state|standard state (at 25 °C, 100 kPa)]]<br />[[wikipedia:Chemical infobox|Infobox disclaimer and references]]</small>
|-
|}
{{Chem-Data_Structure}}

Aldrich MSDS 1, 567:B / Corp MSDS 1 (1), 1054:C / FT-IR 2 (1), 456:B / FT-IR 1 (1), 292:B / IR-Spectra (3), 172:A / IR-Spectra (2), 154:H / NMR-Reference 2 (1), 250:D / RegBook 1 (1), 309:K / Sax 6, 2133 / Sigma FT-IR 1 (2), 6:D / Structure Index 1, 42:A:6 / Vapor Phase 3, 376:B

It07:Roaccutane

2007-10-22T13:40:39Z

Sl1006: /* Roaccutane */

= Roaccutane =

'''Roaccutane''' is one of the trade names of oral isotretinoin, the active ingredient used to treat severe acne. Isotretinoin is a derivative of vitamin A and works by reducing the amount of sebum produced by the skin.

{{Drug-Box |
| Box_Name = Isotretinoin
| ImageFile =[[Image:Rotane.gif|right|Roaccutane 2D image]]
<jmol>
<jmolApplet>
<size>250</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
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Chime
10190711543D
50 50 0 0 1 V2000
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-3.5000 0.0000 -0.1400 C 0 0 0 0 0 0 0 0 0 0 0 0
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-5.3880 1.8960 -2.0160 H 0 0 0 0 0 0 0 0 0 0 0 0
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0.0160 -2.6800 0.6200 H 0 0 0 0 0 0 0 0 0 0 0 0
1.3040 1.0000 -0.0520 H 0 0 0 0 0 0 0 0 0 0 0 0
2.5000 -1.8120 -0.5960 H 0 0 0 0 0 0 0 0 0 0 0 0
3.7040 0.9480 0.0320 H 0 0 0 0 0 0 0 0 0 0 0 0
5.9240 -2.6000 -0.8720 H 0 0 0 0 0 0 0 0 0 0 0 0
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4.4360 -2.2960 -1.8000 H 0 0 0 0 0 0 0 0 0 0 0 0
7.0200 -0.6480 -0.3440 H 0 0 0 0 0 0 0 0 0 0 0 0
7.0320 2.6040 1.1080 H 0 0 0 0 0 0 0 0 0 0 0 0
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M END</inlineContents>
</jmolApplet>
</jmol>
| IUPACName = (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid
| OtherName = (13Z)-retinoic acid, [7t,9t,11t,13c]retinoic acid, 13-cis-vitamin A acid
| CAS_No = 4759-48-2
| ATC_Code =
| PubChem =
| SMILES ='<'nowiki'>'CC1(C)C(/C=C/C(C)=C/C=C/C=C(C)/C(O)=O)=C(C)CCC1'</'nowiki'>'
| Formula = C<sub>20</sub>H<sub>28</sub>O<sub>2</sub>
| MolarMass = 300.44
| Bioavailability =
| Protein_binding
| Metabolism =
| Half_life =
| Excretion =
| Pregnancy_cat =
| Legal_status =
| Routes =
}}

It07:Capreomycin

2007-10-19T13:37:32Z

Sl1006: /* Capreomycin */ opening sentence

== Capreomycin ==
Capreomycin is used in the treatment of Tuberculosis, TB, but its use is limited due to harmful side effects

It07:Capreomycin

2007-10-19T13:21:14Z

Sl1006: New page: == Capreomycin ==

== Capreomycin ==