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https://chemwiki.ch.ic.ac.uk/api.php?action=feedcontributions&feedformat=atom&user=Mha05 ChemWiki - User contributions [en] 2026-05-16T13:42:32Z User contributions MediaWiki 1.43.0 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=7861 It:Lipitor 2006-12-08T12:09:31Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta,<br> delta-dihydroxy-5- <br>(1-methylethyl)-3-phenyl-4- <br>[(phenylamino)carbonyl]-1H-<br> pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |- <br /> | CAS registry number|Bioavailability<br /> | colspan="2" | 15 %<br /> |-<br /> | CAS registry number|Metabolism<br /> | colspan="2" | Liver<br /> |-<br /> | CAS registry number|Half Life<br /> | colspan="2" | 14 Hours<br /> |-<br /> | CAS registry number|Excretion<br /> | colspan="2" | Bile<br /> |-<br /> ! {{chembox header}} colspan="3"| Therapeutic considerations<br /> |- <br /> | CAS registry number|Pregnancy Cat.<br /> | colspan="2" | D(AU) X(US)<br /> |-<br /> | CAS registry number|Legal Status<br /> | colspan="2" | S4(AU) POM(UK) ℞-only(US)<br /> |-<br /> | CAS registry number|Route<br /> | colspan="2" | Oral<br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin also a type of chiral drug) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins. Lipitor is the most potent of all statins.It was introduced in 1996. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> Since 1996, Lipitor (lipitor marked jointly by Parke Davis and Pfizer, co-promoted by Warner-Lambert) had enormous growth in the international market of chiral drug. It has achieved sales up to $4 billion in 1999 (around 3 years of its market) which marked one of the best selling drug in US alone(41% of the US market). Lipitor has reached the worldwide market of cholesterol-reducing drug as the most potent drug in its class. <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will competitively inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br><br /> An aldehyde is reacted with an enol ether to form alcohol '''15'''. The transesterification of the alcohol with NaOMe and methanol results in the methyl ester '''16'''. The enolate of tert-butylacetate ('''17''') is added to the methyl ester furthered by directed reduction to form the syn-1,3-diol '''18'''. The resultant is treated with NaOH in refluxing Toluene to form the cycled hydroxylactone '''19'''. Lastly, acid is used to 'open' the hydroxylactone thus forming a sodium salt which is treated with CaCl2.H2O to yield the atorvastatin (LIPITOR)<br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7856 It:Ceftriaxone 2006-12-08T11:59:30Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. The colour of of its solution ranges from light yellow to amber coloured solution. <br /> <br /> Ceftriaxone can form complexes with transition metals. Different metal complex has different activity against different type of bacteria. Rocephin is one example of the anhydrous Ceftriaxone complex which is a complex of sodium [Na2(ceftria)]. This is because generally, the sodium complex has good overall activity against different type of bacteria and easy to synthesized.<br /> <br /> Some transition metal complex of Ceftriaxone forms in its hydrated form (e.g. [Mn(Ceftria)].2H2O)<br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication of using Rocephin (ceftriaxone sodium)==<br /> Rocephin has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting<br /> <br /> Consumption of Rochepin should be done in caution if you are allergic to peniccilin type antibody, premature babies, and severe kidney diseases. Roceephin should not be consumed for people who is allergic to any active ingreadients, babies with jaundice, low albumin blood levels, inherited blood diseases.<br /> <br /> == External Link ==<br /> *[http://www2.netdoctor.co.uk/medicines/100003884.html net doctor]<br /> *[http://www.rocheusa.com/products/rocephin/pi.pdf Official Link]<br /> *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a685032.html Medicine Plus Drug Information]<br /> *[http://www.rxlist.com/cgi/generic3/ceftriax.htm rxlist]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7855 It:Ceftriaxone 2006-12-08T11:58:51Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. The colour of of its solution ranges from light yellow to amber coloured solution. <br /> <br /> Ceftriaxone can form complexes with transition metals. Different metal complex has different activity against different type of bacteria. Rocephin is one example of the anhydrous Ceftriaxone complex which is a complex of sodium [Na2(ceftria)]. This is because generally, the sodium complex has good overall activity against different type of bacteria and easy to synthesized.<br /> <br /> Some transition metal complex of Ceftriaxone forms in its hydrated form (e.g. [Mn(Ceftria)].2H2O)<br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication of using ROcephin (ceftriaxone sodium)==<br /> Rocephin has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting<br /> <br /> Consumption of Rochepin should be done in caution if you are allergic to peniccilin type antibody, premature babies, and severe kidney diseases. Roceephin should not be consumed for people who is allergic to any active ingreadients, babies with jaundice, low albumin blood levels, inherited blood diseases.<br /> <br /> == External Link ==<br /> *[http://www2.netdoctor.co.uk/medicines/100003884.html net doctor]<br /> *[http://www.rocheusa.com/products/rocephin/pi.pdf Official Link]<br /> *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a685032.html Medicine Plus Drug Information]<br /> *[http://www.rxlist.com/cgi/generic3/ceftriax.htm rxlist]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7851 It:Ceftriaxone 2006-12-08T11:53:35Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. The colour of of its solution ranges from light yellow to amber coloured solution. <br /> <br /> Ceftriaxone can form complexes with metals. Different metal complex has different activity against different type of bacteria. Rocephin is one example of the anhydrous Ceftriaxone complex which is a complex of sodium [Na2(ceftria)]. This is because generally, the sodium complex has good overall activity against different type of bacteria and easy to synthesized.<br /> <br /> Some metal complex of Ceftriaxone forms in its hydrated form (e.g. [Mn(Ceftria)].2H2O<br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication ==<br /> Ceftriaxone has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting<br /> <br /> Consumption of Ceftriaxone should be done in caution if you are allergic to peniccilin type antibody, premature babies, and severe kidney diseases. Ceftriaxone should not be consumed for people who is allergic to any active ingreadients, babies with jaundice, low albumin blood levels, inherited blood diseases.<br /> <br /> == External Link ==<br /> *[http://www2.netdoctor.co.uk/medicines/100003884.html net doctor]<br /> *[http://www.rocheusa.com/products/rocephin/pi.pdf Official Link]<br /> *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a685032.html Medicine Plus Drug Information]<br /> *[http://www.rxlist.com/cgi/generic3/ceftriax.htm rxlist]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7846 It:Ceftriaxone 2006-12-08T11:47:11Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. The colour of of its solution ranges from light yellow to amber coloured solution. <br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication ==<br /> Ceftriaxone has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting<br /> <br /> Consumption of Ceftriaxone should be done in caution if you are allergic to peniccilin type antibody, premature babies, and severe kidney diseases. Ceftriaxone should not be consumed for people who is allergic to any active ingreadients, babies with jaundice, low albumin blood levels, inherited blood diseases.<br /> <br /> == External Link ==<br /> *[http://www2.netdoctor.co.uk/medicines/100003884.html net doctor]<br /> *[http://www.rocheusa.com/products/rocephin/pi.pdf Official Link]<br /> *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a685032.html Medicine Plus Drug Information]<br /> *[http://www.rxlist.com/cgi/generic3/ceftriax.htm rxlist]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7839 It:Ceftriaxone 2006-12-08T11:38:36Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. <br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication ==<br /> Ceftriaxone has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting<br /> <br /> == External Link ==<br /> *[http://www2.netdoctor.co.uk/medicines/100003884.html net doctor]<br /> *[http://www.rocheusa.com/products/rocephin/pi.pdf Official Link]<br /> *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a685032.html Medicine Plus Drug Information]<br /> *[http://www.rxlist.com/cgi/generic3/ceftriax.htm rxlist]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7836 It:Ceftriaxone 2006-12-08T11:35:28Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. <br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.<br /> <br /> == Health Complication ==<br /> Ceftriaxone has some side effects concerning of its use:[http://www2.netdoctor.co.uk/medicines/100003884.html Side effect]<br /> *Headache<br /> *Rash<br /> *Diarrhoea<br /> *Pruritus (Ithcing)<br /> *Allergic Reaction<br /> *Inflammation at site or injection, Pancreas (Pancreatitis), Large Intestines (Colitis)<br /> *Dizzines<br /> *Nausea and Vomiting<br /> *Increase time for Blood clotting</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7827 It:Ceftriaxone 2006-12-08T11:28:59Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea. It is a third-generation cephalosporin antibiotic which has a broad spectrum activity against Gram Positive and Gram negative Bacterias.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. <br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7822 It:Ceftriaxone 2006-12-08T11:27:09Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly with a usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> <br /> == Chemistry ==<br /> Ceftriaxone is a yellowish-orange powder. It has readily-soluble in water, partly soluble in methanol and almost insoluble in ethanol. THe 1% aqueous solution has a pH of 6.7. <br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7816 It:Ceftriaxone 2006-12-08T11:23:44Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea.<br /> <br /> Ceftriaxone Sodium is marketed internationally by Hoffman-La Roche under the brand name Rocephin<br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly witha usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Ceftriaxone&diff=7814 It:Ceftriaxone 2006-12-08T11:21:19Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Ceftriaxone<br /> |-<br /> ! {{chembox header}} colspan="3" |Structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[Image:Ceftriaxone.png|200px|Ceftriaxone]] <br /> |-<br /> ! {{chembox header}} colspan="3" |3D structure<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | <jmol><br /> <jmolApplet><br /> <size>200</size><br /> <color>white</color><br /> <script>zoom 100; cpk off;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>REMARK MSI WebLab Viewer PDB file<br /> REMARK Created: Fri Oct 20 12:51:30 GMT Standard Time 2006<br /> ATOM 1 N 0 -9.077 1.857 -0.122 0.00 0.00<br /> ATOM 2 C 0 -8.278 0.728 -0.196 0.00 0.00<br /> ATOM 3 N 0 -6.981 0.610 0.017 0.00 0.00<br /> ATOM 4 C 0 -6.368 -0.567 -0.099 0.00 0.00<br /> ATOM 5 C 0 -4.914 -0.681 0.144 0.00 0.00<br /> ATOM 6 C 0 -4.077 0.540 0.215 0.00 0.00<br /> ATOM 7 N 0 -2.751 0.436 0.436 0.00 0.00<br /> ATOM 8 C 0 -1.924 1.643 0.507 0.00 0.00<br /> ATOM 9 H 0 -2.488 2.527 0.804 0.00 0.00<br /> ATOM 10 C 0 -0.628 1.452 1.290 0.00 0.00<br /> ATOM 11 H 0 -0.366 2.265 1.966 0.00 0.00<br /> ATOM 12 N 0 0.045 1.470 -0.046 0.00 0.00<br /> ATOM 13 C 0 1.350 1.029 -0.326 0.00 0.00<br /> ATOM 14 C 0 2.034 1.452 -1.561 0.00 0.00<br /> ATOM 15 O 0 2.018 0.656 -2.648 0.00 0.00<br /> ATOM 16 O 0 2.613 2.520 -1.599 0.00 0.00<br /> ATOM 17 C 0 1.957 0.225 0.538 0.00 0.00<br /> ATOM 18 C 0 3.333 -0.248 0.144 0.00 0.00<br /> ATOM 19 S 0 4.579 0.682 1.072 0.00 0.00<br /> ATOM 20 C 0 6.047 -0.054 0.434 0.00 0.00<br /> ATOM 21 N 0 5.952 -1.008 -0.472 0.00 0.00<br /> ATOM 22 C 0 7.050 -1.583 -0.973 0.00 0.00<br /> ATOM 23 C 0 8.372 -1.143 -0.504 0.00 0.00<br /> ATOM 24 O 0 9.504 -1.709 -0.996 0.00 0.00<br /> ATOM 25 N 0 8.438 -0.194 0.395 0.00 0.00 <br /> ATOM 26 N 0 7.253 0.376 0.880 0.00 0.00<br /> ATOM 27 C 0 7.319 1.438 1.887 0.00 0.00<br /> ATOM 28 O 0 6.956 -2.466 -1.811 0.00 0.00<br /> ATOM 29 C 0 1.447 -0.268 1.850 0.00 0.00<br /> ATOM 30 S 0 -0.373 -0.214 1.982 0.00 0.00<br /> ATOM 31 C 0 -1.054 1.858 -0.721 0.00 0.00<br /> ATOM 32 O 0 -1.267 2.231 -1.855 0.00 0.00<br /> ATOM 33 H 0 -2.345 -0.438 0.549 0.00 0.00<br /> ATOM 34 O 0 -4.585 1.634 0.074 0.00 0.00<br /> ATOM 35 N 0 -4.368 -1.854 0.295 0.00 0.00<br /> ATOM 36 O 0 -5.160 -3.023 0.179 0.00 0.00<br /> ATOM 37 C 0 -4.288 -4.135 0.394 0.00 0.00<br /> ATOM 38 C 0 -7.101 -1.670 -0.446 0.00 0.00<br /> ATOM 39 S 0 -8.732 -0.953 -0.596 0.00 0.00<br /> ATOM 40 H 0 -8.687 2.713 0.115 0.00 0.00<br /> ATOM 41 H 0 -10.026 1.792 -0.311 0.00 0.00<br /> ATOM 42 H 0 2.467 0.934 -3.458 0.00 0.00<br /> ATOM 43 H 0 3.430 -1.310 0.369 0.00 0.00<br /> ATOM 44 H 0 3.481 -0.087 -0.923 0.00 0.00<br /> ATOM 45 H 0 9.226 -2.376 -1.639 0.00 0.00<br /> ATOM 46 H 0 8.361 1.645 2.130 0.00 0.00<br /> ATOM 47 H 0 6.851 2.340 1.494 0.00 0.00<br /> ATOM 48 H 0 6.792 1.118 2.787 0.00 0.00<br /> ATOM 49 H 0 1.781 -1.296 1.993 0.00 0.00<br /> ATOM 50 H 0 1.868 0.349 2.644 0.00 0.00<br /> ATOM 51 H 0 -4.855 -5.062 0.314 0.00 0.00<br /> ATOM 52 H 0 -3.498 -4.127 -0.357 0.00 0.00<br /> ATOM 53 H 0 -3.846 -4.064 1.387 0.00 0.00 <br /> ATOM 54 H 0 -6.783 -2.693 -0.586 0.00 0.00 <br /> TER<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> ! {{chembox header}} colspan="3" | General<br /> |- <br /> | colspan="1" |[http://en.wikipedia.org/wiki/IUPAC_nomenclature Systematic name]<br /> | colspan="2"|(6''R'',7''R'',''Z'')-7-(2-(2-aminothiazol-4-yl)-2-<br />(methoxyimino)acetamido)-3-((6-hydroxy<br />-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin<br />-3-ylthio)methyl)-8-oxo-5-thia-1-aza-bicyclo<br />[4.2.0]oct-2-ene-2-carboxylic acid<br /> |-<br /> | colspan="1" |Synonyms<br /> | colspan="2" |Rocephin<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Chemical_formula Molecular formula]<br /> | colspan="2" |C<sub>18</sub>H<sub>18</sub>N<sub>8</sub>O<sub>7</sub>S<sub>3</sub><br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Simplified_molecular_input_line_entry_specification SMILES]<br /> | colspan="2" |NC1=NC(/C(C(N([C@@H]([C@@H]3N2C<br />(C(O)=O)=C(CSC4=NC(C(O)=NN4C)=O)<br />CS3)C2=O)[H])=O)=N\OC)=CS1<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/Molar_mass Molar mass]<br /> | colspan="2" |554.58 g/mol<br /> |-<br /> | colspan="1" |Appearance<br /> | colspan="2" |Yellow-orange crystalline powder<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/CAS_registry_number CAS number]<br /> | colspan="2" |63527-52-6<br /> |-<br /> | colspan="1" |[http://en.wikipedia.org/wiki/ATC_code ATC Code]<br /> | colspan="2" |J01DD01<br /> |-<br /> ! {{chembox header}} colspan="3"| Properties<br /> |-<br /> | [http://en.wikipedia.org/wiki/Density Density] and [http://en.wikipedia.org/wiki/Phase_%28matter%29 Phase]<br /> | colspan="2" |g/cm<sup>3</sup>, solid<br /> |-<br /> | [http://en.wikipedia.org/wiki/Solubility Solubility] in [http://en.wikipedia.org/wiki/Water_%28molecule%29 water]<br /> | colspan="2" |readily-soluble<br /> |-<br /> | Other solvents<br /> | colspan="2" |Methanol (sparingly)<br />Ethanol (slightly)<br /> |- <br /> <br /> |-<br /> | [http://en.wikipedia.org/wiki/pH p''H''] <br /> | colspan="2" |6.7 (1% aqueous solution)<br /> |-<br /> ! {{chembox header}} colspan="3"| Pharmacokinetic data<br /> |-<br /> | [http://en.wikipedia.org/wiki/Bioavailability Bioavailability]<br /> | colspan="2" |n/a<br /> |-<br /> | [http://en.wikipedia.org/wiki/Metabolism Metabolism]<br /> | colspan="2" |negligible<br /> |-<br /> | [http://en.wikipedia.org/wiki/Elimination_half-life Half life]<br /> | colspan="2" | 5.8-8.7 hours<br /> |- <br /> | [http://en.wikipedia.org/wiki/Excretion Excretion]<br /> | colspan="2" | [http://en.wikipedia.org/wiki/biliary Biliary], [http://en.wikipedia.org/wiki/renal Renal]<br /> <br /> |-<br /> | {{chembox header}} colspan="3"| <small>Except where noted otherwise, data are given for<br> materials in their [http://en.wikipedia.org/wiki/Standard_state standard state (at 25 &deg;C, 100 kPa)]<br/>[http://en.wikipedia.org/wiki/Wikipedia:Chemical_infobox Infobox disclaimer and references]]</small><br /> |-<br /> |}<br /> <br /> '''Ceftriaxone''' is a cephalosporin antibiotic which has been used in the treatment of pneumonia, bacterial meningitis, Lyme's Disease and gonorrhoea.<br /> <br /> <br /> == Routes of administration ==<br /> <br /> Ceftriaxone is injected either intravenously or intramuscularly witha usual starting dose of between 1 and 2 grams every 12-24 hours.<br /> <br /> == Treatment of gonorrhoea ==<br /> <br /> In the treatment of gonorrhoea a single intramuscular dose of 250mg is administered, most commonly in combination with [[It:Azithromycin|azithromycin]], a treatment for [http://en.wikipedia.org/wiki/chlamydia chlamydia].<br /> <br /> == Microbiology ==<br /> Ceftriaxone works by interfering with the formation of cell walls in the bacteria causing the disease. This leaves the bacteria without a cell wall and only a membrance, making it very vulnerable and weak. This causes it to break down and die in time, preventing the disease from developing any further.</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=6925 It:Lipitor 2006-12-05T12:22:19Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta,<br> delta-dihydroxy-5- <br>(1-methylethyl)-3-phenyl-4- <br>[(phenylamino)carbonyl]-1H-<br> pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin also a type of chiral drug) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins. Lipitor is the most potent of all statins.It was introduced in 1996. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> Since 1996, Lipitor (lipitor marked jointly by Parke Davis and Pfizer, co-promoted by Warner-Lambert) had enormous growth in the international market of chiral drug. It has achieved sales up to $4 billion in 1999 (around 3 years of its market) which marked one of the best selling drug in US alone(41% of the US market). Lipitor has reached the worldwide market of cholesterol-reducing drug as the most potent drug in its class. <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will competitively inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br><br /> An aldehyde is reacted with an enol ether to form alcohol '''15'''. The transesterification of the alcohol with NaOMe and methanol results in the methyl ester '''16'''. The enolate of tert-butylacetate ('''17''') is added to the methyl ester furthered by directed reduction to form the syn-1,3-diol '''18'''. The resultant is treated with NaOH in refluxing Toluene to form the cycled hydroxylactone '''19'''. Lastly, acid is used to 'open' the hydroxylactone thus forming a sodium salt which is treated with CaCl2.H2O to yield the atorvastatin (LIPITOR)<br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=6923 It:Lipitor 2006-12-05T12:12:33Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta,<br> delta-dihydroxy-5- <br>(1-methylethyl)-3-phenyl-4- <br>[(phenylamino)carbonyl]-1H-<br> pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins. Lipitor is the most potent of all statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will competitively inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br><br /> An aldehyde is reacted with an enol ether to form alcohol '''15'''. The transesterification of the alcohol with NaOMe and methanol results in the methyl ester '''16'''. The enolate of tert-butylacetate ('''17''') is added to the methyl ester furthered by directed reduction to form the syn-1,3-diol '''18'''. The resultant is treated with NaOH in refluxing Toluene to form the cycled hydroxylactone '''19'''. Lastly, acid is used to 'open' the hydroxylactone thus forming a sodium salt which is treated with CaCl2.H2O to yield the atorvastatin (LIPITOR)<br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=6490 It:Lipitor 2006-12-01T12:17:54Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta,<br> delta-dihydroxy-5- <br>(1-methylethyl)-3-phenyl-4- <br>[(phenylamino)carbonyl]-1H-<br> pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will competitively inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5695 It:Lipitor 2006-11-20T16:06:51Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will competitively inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5694 It:Lipitor 2006-11-20T16:05:40Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol is not water soluble thus it travels in the human body in the form of lipoprotein. Once it reaches the human artery, it can cause a buildup of plaque in the lumen wall, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>500</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0<br /> ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0<br /> ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0<br /> ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0<br /> ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0<br /> ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0<br /> ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0<br /> ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0<br /> ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0<br /> ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0<br /> ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0<br /> ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0<br /> ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0<br /> ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0<br /> ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0<br /> ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0<br /> ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0<br /> ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0<br /> ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0<br /> ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0<br /> ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0<br /> ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0<br /> ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0<br /> ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0<br /> ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0<br /> ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0<br /> ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0<br /> ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0<br /> ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0<br /> ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0<br /> ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0<br /> ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0<br /> ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0<br /> ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0<br /> ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0<br /> ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0<br /> ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0<br /> ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0<br /> ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0<br /> ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0<br /> ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0<br /> ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0<br /> ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0<br /> ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0<br /> ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0<br /> ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0<br /> ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0<br /> ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0<br /> ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0<br /> ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0<br /> ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0<br /> ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0<br /> ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0<br /> ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0<br /> ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0<br /> ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0<br /> ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0<br /> CONECT 1 2 41 0 0 NONE 71<br /> CONECT 2 1 3 4 12 NONE 72<br /> CONECT 4 2 5 42 43 NONE 73<br /> CONECT 5 4 6 7 8 NONE 74<br /> CONECT 7 5 44 0 0 NONE 75<br /> CONECT 8 5 9 45 46 NONE 76<br /> CONECT 9 8 10 11 0 NONE 77<br /> CONECT 10 9 0 0 0 NONE 78<br /> CONECT 11 9 0 0 0 NONE 79<br /> CONECT 12 2 13 47 48 NONE 80<br /> CONECT 13 12 14 49 50 NONE 81<br /> CONECT 14 13 15 26 0 NONE 82<br /> CONECT 15 14 16 51 0 NONE 83<br /> CONECT 16 15 27 17 0 NONE 84<br /> CONECT 17 16 18 25 0 NONE 85<br /> CONECT 18 17 19 52 0 NONE 86<br /> CONECT 19 18 24 20 0 NONE 87<br /> CONECT 20 19 21 53 0 NONE 88<br /> CONECT 21 20 22 54 0 NONE 89<br /> CONECT 22 21 23 55 0 NONE 90<br /> CONECT 23 22 24 56 0 NONE 91<br /> CONECT 24 23 19 57 0 NONE 92<br /> CONECT 25 17 0 0 0 NONE 93<br /> CONECT 26 14 27 58 0 NONE 94<br /> CONECT 27 26 16 28 0 NONE 95<br /> CONECT 28 27 33 29 0 NONE 96<br /> CONECT 29 28 30 59 0 NONE 97<br /> CONECT 30 29 31 60 0 NONE 98<br /> CONECT 31 30 32 61 0 NONE 99<br /> CONECT 32 31 33 62 0 NONE 100<br /> CONECT 33 32 28 34 0 NONE 101<br /> CONECT 34 33 40 35 0 NONE 102<br /> CONECT 35 34 36 63 0 NONE 103<br /> CONECT 36 35 37 64 0 NONE 104<br /> CONECT 37 36 38 39 0 NONE 105<br /> CONECT 38 37 0 0 0 NONE 106<br /> CONECT 39 37 40 65 0 NONE 107<br /> CONECT 40 39 34 66 0 NONE 108<br /> END NONE 109<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf<br /> *http://www.molecular-networks.com/online_demos/corina_demo.html</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5682 It:Lipitor 2006-11-20T15:58:41Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor3.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>800</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0<br /> ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0<br /> ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0<br /> ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0<br /> ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0<br /> ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0<br /> ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0<br /> ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0<br /> ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0<br /> ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0<br /> ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0<br /> ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0<br /> ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0<br /> ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0<br /> ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0<br /> ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0<br /> ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0<br /> ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0<br /> ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0<br /> ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0<br /> ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0<br /> ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0<br /> ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0<br /> ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0<br /> ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0<br /> ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0<br /> ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0<br /> ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0<br /> ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0<br /> ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0<br /> ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0<br /> ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0<br /> ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0<br /> ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0<br /> ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0<br /> ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0<br /> ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0<br /> ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0<br /> ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0<br /> ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0<br /> ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0<br /> ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0<br /> ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0<br /> ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0<br /> ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0<br /> ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0<br /> ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0<br /> CONECT 1 2 34 0 0 NONE 61<br /> CONECT 2 1 3 4 12 NONE 62<br /> CONECT 4 2 5 35 36 NONE 63<br /> CONECT 5 4 6 7 8 NONE 64<br /> CONECT 7 5 37 0 0 NONE 65<br /> CONECT 8 5 9 38 39 NONE 66<br /> CONECT 9 8 10 11 0 NONE 67<br /> CONECT 10 9 0 0 0 NONE 68<br /> CONECT 11 9 0 0 0 NONE 69<br /> CONECT 12 2 13 40 41 NONE 70<br /> CONECT 13 12 14 42 43 NONE 71<br /> CONECT 14 13 15 26 0 NONE 72<br /> CONECT 15 14 16 44 0 NONE 73<br /> CONECT 16 15 27 17 0 NONE 74<br /> CONECT 17 16 18 25 0 NONE 75<br /> CONECT 18 17 19 45 0 NONE 76<br /> CONECT 19 18 24 20 0 NONE 77<br /> CONECT 20 19 21 46 0 NONE 78<br /> CONECT 21 20 22 47 0 NONE 79<br /> CONECT 22 21 23 48 0 NONE 80<br /> CONECT 23 22 24 49 0 NONE 81<br /> CONECT 24 23 19 50 0 NONE 82<br /> CONECT 25 17 0 0 0 NONE 83<br /> CONECT 26 14 27 51 0 NONE 84<br /> CONECT 27 26 16 28 0 NONE 85<br /> CONECT 28 27 33 29 0 NONE 86<br /> CONECT 29 28 30 52 0 NONE 87<br /> CONECT 30 29 31 53 0 NONE 88<br /> CONECT 31 30 32 54 0 NONE 89<br /> CONECT 32 31 33 55 0 NONE 90<br /> CONECT 33 32 28 56 0 NONE 91<br /> END NONE 92<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]<br /> <br /> == Reference Link ==<br /> <br /> *[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]<br /> *http://www.drugs.com/lipitor.html<br /> *http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm<br /> *http://organicdivision.org/essays_2001/schaus.pdf</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5672 It:Lipitor 2006-11-20T15:52:42Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.<br /> [http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. <br /> <br /> == Synthesis ==<br /> [[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]<br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor2.gif|centre|100|image produced in chemdraw]]<br /> <br /> == 3D Structure ==<br /> <br /> <jmol><br /> <jmolApplet><br /> <size>800</size><br /> <color>white</color><br /> <script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script><br /> <inlineContents>water.mol<br /> title1<br /> title2<br /> ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0<br /> ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0<br /> ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0<br /> ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0<br /> ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0<br /> ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0<br /> ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0<br /> ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0<br /> ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0<br /> ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1<br /> ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0<br /> ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0<br /> ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0<br /> ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0<br /> ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0<br /> ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0<br /> ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0<br /> ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0<br /> ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0<br /> ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0<br /> ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0<br /> ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0<br /> ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0<br /> ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0<br /> ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0<br /> ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0<br /> ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0<br /> ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0<br /> ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0<br /> ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0<br /> ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0<br /> ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0<br /> ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0<br /> ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0<br /> ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0<br /> ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0<br /> ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0<br /> ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0<br /> ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0<br /> ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0<br /> ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0<br /> ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0<br /> ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0<br /> ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0<br /> ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0<br /> ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0<br /> ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0<br /> ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0<br /> ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0<br /> ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0<br /> ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0<br /> ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0<br /> ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0<br /> ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0<br /> ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0<br /> ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0<br /> CONECT 1 2 34 0 0 NONE 61<br /> CONECT 2 1 3 4 12 NONE 62<br /> CONECT 4 2 5 35 36 NONE 63<br /> CONECT 5 4 6 7 8 NONE 64<br /> CONECT 7 5 37 0 0 NONE 65<br /> CONECT 8 5 9 38 39 NONE 66<br /> CONECT 9 8 10 11 0 NONE 67<br /> CONECT 10 9 0 0 0 NONE 68<br /> CONECT 11 9 0 0 0 NONE 69<br /> CONECT 12 2 13 40 41 NONE 70<br /> CONECT 13 12 14 42 43 NONE 71<br /> CONECT 14 13 15 26 0 NONE 72<br /> CONECT 15 14 16 44 0 NONE 73<br /> CONECT 16 15 27 17 0 NONE 74<br /> CONECT 17 16 18 25 0 NONE 75<br /> CONECT 18 17 19 45 0 NONE 76<br /> CONECT 19 18 24 20 0 NONE 77<br /> CONECT 20 19 21 46 0 NONE 78<br /> CONECT 21 20 22 47 0 NONE 79<br /> CONECT 22 21 23 48 0 NONE 80<br /> CONECT 23 22 24 49 0 NONE 81<br /> CONECT 24 23 19 50 0 NONE 82<br /> CONECT 25 17 0 0 0 NONE 83<br /> CONECT 26 14 27 51 0 NONE 84<br /> CONECT 27 26 16 28 0 NONE 85<br /> CONECT 28 27 33 29 0 NONE 86<br /> CONECT 29 28 30 52 0 NONE 87<br /> CONECT 30 29 31 53 0 NONE 88<br /> CONECT 31 30 32 54 0 NONE 89<br /> CONECT 32 31 33 55 0 NONE 90<br /> CONECT 33 32 28 56 0 NONE 91<br /> END NONE 92<br /> </inlineContents><br /> </jmolApplet><br /> </jmol><br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=File:Atorvastatin_synthesis.JPG&diff=5665 File:Atorvastatin synthesis.JPG 2006-11-20T15:48:01Z

<p>Mha05: </p> <hr /> <div></div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5638 It:Lipitor 2006-11-20T15:30:03Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |Systematic IUPAC Name<br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.<br /> <br /> <br /> == Structure ==<br /> <br /> [[Image:lipitor2.gif|centre|100|image produced in chemdraw]]<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5632 It:Lipitor 2006-11-20T15:25:41Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |2D Structure of Lipitor(Atorvastatin)<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[ ]] <br /> <br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> <br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *bruising<br /> *chest pain<br /> *headache<br /> *itching<br /> *difficulty with memory/ thinking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5627 It:Lipitor 2006-11-20T15:19:22Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |2D Structure of Lipitor(Atorvastatin)<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[ ]] <br /> <br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> <br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *Bruising<br /> *chest pain<br /> *headache<br /> *Itching<br /> *difficulty with memory/ thingking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5626 It:Lipitor 2006-11-20T15:18:10Z

<p>Mha05: </p> <hr /> <div>{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"<br /> ! {{chembox header}} colspan="3" |2D Structure of Lipitor(Atorvastatin)<br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" | [[ ]] <br /> <br /> |-<br /> | align="center" colspan="3" bgcolor="#ffffff" |<br /> |- <br /> <br /> |-<br /> | Systematic Iupac Name<br /> | colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|- <br /> |- <br /> ! {{chembox header}} colspan="3"| Identifiers<br /> |- <br /> | CAS registry number|CAS number<br /> | colspan="2" | 134523-00-5<br /> |-<br /> | CAS registry number|ATC Code<br /> | colspan="2" | C10AA05<br /> |-<br /> | CAS registry number|Pub Chem<br /> | colspan="2" | 60823<br /> |-<br /> | CAS registry number|Drug Bank<br /> | colspan="2" | APRD00055<br /> |-<br /> |- <br /> ! {{chembox header}} colspan="3"| Chemical Data<br /> |- <br /> | Chemical formula|Molecular formula<br /> | colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F <br /> |-<br /> | Molar mass<br /> | colspan="2" | 558.64 g/mol<br /> |-<br /> <br /> <br /> |}<br /> <br /> Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *Bruising<br /> *chest pain<br /> *headache<br /> *Itching<br /> *difficulty with memory/ thingking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5604 It:Lipitor 2006-11-20T14:52:21Z

<p>Mha05: </p> <hr /> <div>Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *Bruising<br /> *chest pain<br /> *headache<br /> *Itching<br /> *difficulty with memory/ thingking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5602 It:Lipitor 2006-11-20T14:47:11Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:[http://http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]<br /> *allergic reaction<br /> *loss of appetite<br /> *Bruising<br /> *chest pain<br /> *headache<br /> *Itching<br /> *difficulty with memory/ thingking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5600 It:Lipitor 2006-11-20T14:46:27Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:<br /> *allergic reaction<br /> *loss of appetite<br /> *Bruising<br /> *chest pain<br /> *headache<br /> *Itching<br /> *difficulty with memory/ thingking<br /> *numbness in hand and feet<br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5599 It:Lipitor 2006-11-20T14:43:16Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> Lipitor can cause a number of side effect:<br /> <br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5595 It:Lipitor 2006-11-20T14:36:13Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor).It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine<br /> <br /> <br /> There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5593 It:Lipitor 2006-11-20T14:26:24Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor).It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5592 It:Lipitor 2006-11-20T14:22:05Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor). It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.<br /> <br /> <br /> == How does it works ==<br /> <br /> LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will block an enzyme in the liver which is used to produce the LDL cholesterol.<br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5589 It:Lipitor 2006-11-20T14:13:03Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor). It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.<br /> <br /> <br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5588 It:Lipitor 2006-11-20T14:11:44Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor). It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.<br /> <br /> <br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring duce to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5587 It:Lipitor 2006-11-20T14:08:34Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor). It is used to block the production of cholesterol in the human body.<br /> <br /> <br /> <br /> == Health Complication ==<br /> <br /> Lipitor have been associated with muscle pain and Liver problems. The symptoms occuring duce to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5584 It:Lipitor 2006-11-20T14:02:15Z

<p>Mha05: </p> <hr /> <div>Lipitor is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor). It is used to block the production of cholesterol in the human body.</div>

Mha05 https://chemwiki.ch.ic.ac.uk/index.php?title=It:Lipitor&diff=5581 It:Lipitor 2006-11-20T14:00:21Z

<p>Mha05: </p> <hr /> <div>Lipitor is a type of HMG CoA reductase inhibitor. It is used to block the production of cholesterol in the human body.</div>

Mha05