ChemWiki - User contributions [en]

It:Flucloxacillin

2006-12-04T14:49:33Z

Ah505: /* Description */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Pregnancy and Breastfeeding ==

Certain medicines should not be used during pregnancy or breastfeeding. Fortunatally there are no known harmful effects when taking this medicine during pregnancy, however, as with all medicines it should be used with caution during pregnancy and only if the expected benefits outweigh any potential risks to the unborn baby. If unsure seek further medical advice from your doctor.

When taking this medication whilst breast feeding small amounts of the medicine passes into breast milk, this amount is unlikely to harm the nursing infant.

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

==== Description ====

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chemical header}}|
|-align="center" colspan="1" bgcolor="#ffffff" |
|}

{| class="toccolours" border="1" style="float: center; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
|- bgcolor = "#ffffff"
! {{chemical header}}| '''Chemical Data'''
|
|-
| [http://www.iupac.org/dhtml_home.html Systematic (IUPAC) name]
| 6-((S)-3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-
4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0]heptane-2-carboxylic acid
|-
| Molecular formula
|C<sub>19</sub>H<sub>17</sub>N<sub>3</sub>Cl<sub></sub>F<sub></sub>O<sub>5</sub>S<sub></sub>
|-
| Molecular mass
| 453.87 g/mol
|-
| Half life
| 0.75-1 hour
|-
| [http://www.cas.org/ CAS number]
| 5250-39-5
|-
|}

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html
* http://en.wikipedia.org/wiki/Flucloxacillin

It:Flucloxacillin

2006-12-04T14:48:51Z

Ah505: /* References */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Pregnancy and Breastfeeding ==

Certain medicines should not be used during pregnancy or breastfeeding. Fortunatally there are no known harmful effects when taking this medicine during pregnancy, however, as with all medicines it should be used with caution during pregnancy and only if the expected benefits outweigh any potential risks to the unborn baby. If unsure seek further medical advice from your doctor.

When taking this medication whilst breast feeding small amounts of the medicine passes into breast milk, this amount is unlikely to harm the nursing infant.

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

==== Description ====
White, crystalline alkaloid with a bitter taste.

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chemical header}}|
|-align="center" colspan="1" bgcolor="#ffffff" |
|}

{| class="toccolours" border="1" style="float: center; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
|- bgcolor = "#ffffff"
! {{chemical header}}| '''Chemical Data'''
|
|-
| [http://www.iupac.org/dhtml_home.html Systematic (IUPAC) name]
| 6-((S)-3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-
4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0]heptane-2-carboxylic acid
|-
| Molecular formula
|C<sub>19</sub>H<sub>17</sub>N<sub>3</sub>Cl<sub></sub>F<sub></sub>O<sub>5</sub>S<sub></sub>
|-
| Molecular mass
| 453.87 g/mol
|-
| Half life
| 0.75-1 hour
|-
| [http://www.cas.org/ CAS number]
| 5250-39-5
|-
|}

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html
* http://en.wikipedia.org/wiki/Flucloxacillin

It:Flucloxacillin

2006-12-04T14:48:04Z

Ah505: /* Structure */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Pregnancy and Breastfeeding ==

Certain medicines should not be used during pregnancy or breastfeeding. Fortunatally there are no known harmful effects when taking this medicine during pregnancy, however, as with all medicines it should be used with caution during pregnancy and only if the expected benefits outweigh any potential risks to the unborn baby. If unsure seek further medical advice from your doctor.

When taking this medication whilst breast feeding small amounts of the medicine passes into breast milk, this amount is unlikely to harm the nursing infant.

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

==== Description ====
White, crystalline alkaloid with a bitter taste.

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chemical header}}|
|-align="center" colspan="1" bgcolor="#ffffff" |
|}

{| class="toccolours" border="1" style="float: center; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
|- bgcolor = "#ffffff"
! {{chemical header}}| '''Chemical Data'''
|
|-
| [http://www.iupac.org/dhtml_home.html Systematic (IUPAC) name]
| 6-((S)-3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-
4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo
[3.2.0]heptane-2-carboxylic acid
|-
| Molecular formula
|C<sub>19</sub>H<sub>17</sub>N<sub>3</sub>Cl<sub></sub>F<sub></sub>O<sub>5</sub>S<sub></sub>
|-
| Molecular mass
| 453.87 g/mol
|-
| Half life
| 0.75-1 hour
|-
| [http://www.cas.org/ CAS number]
| 5250-39-5
|-
|}

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html

It:Flucloxacillin

2006-12-04T14:37:27Z

Ah505: /* Side Effect */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Pregnancy and Breastfeeding ==

Certain medicines should not be used during pregnancy or breastfeeding. Fortunatally there are no known harmful effects when taking this medicine during pregnancy, however, as with all medicines it should be used with caution during pregnancy and only if the expected benefits outweigh any potential risks to the unborn baby. If unsure seek further medical advice from your doctor.

When taking this medication whilst breast feeding small amounts of the medicine passes into breast milk, this amount is unlikely to harm the nursing infant.

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html

It:Flucloxacillin

2006-12-04T14:29:06Z

Ah505: /* Structure */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html

It:Flucloxacillin

2006-12-04T14:28:23Z

Ah505: /* Structure */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Structure ==
[[Image:flucloxacillin.gif|left|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html

It:Flucloxacillin

2006-11-24T12:06:22Z

Ah505: /* References */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

* www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100001071_2.html

It:Flucloxacillin

2006-11-24T12:05:33Z

Ah505: /* 3D Structure */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

== References ==

It:Flucloxacillin

2006-11-24T12:05:12Z

Ah505: /* Side Effect */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
* Rash
* Itching
* Nausea and vomiting
* Diarrhoea
* Yellowing of the skin and eyes

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

It:Flucloxacillin

2006-11-24T12:02:22Z

Ah505: /* Side Effects */

== About Flucloxacillin ==

Flucloxacillin is a antibiotic which is part of the penicillin group. It works by breaking down the wall of the bacteria cells invading the body and therefore forcing them break up and dye.
Flucloxacillin is used when the bacteria present in the body is a penicillin resistant bacteria call staphylococci. This can be used to break down this bacteria as it is not broken down by the penicillinase enzyme that is produced by this group of bacteria.

== When is it used ==

Flucloxacillin is usually used when a patient is suffering from various inferctions, such as: bond and joint; skin and wound; organs involved in breathing and the inflammation of the lining of the heart cavity and valves due to the bacteria staphylococcus.

== Side Effect ==

The side effects to taking this medication varys depending on the indivdual. Some people will suffer from any of the following side effects and others will have none.
1.
2.
3

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

It:Flucloxacillin

2006-11-24T11:57:59Z

Ah505: /* When is it used */

It:Flucloxacillin

2006-11-24T11:57:14Z

Ah505: /* About Flucloxacillin */

It:Flucloxacillin

2006-11-24T11:45:53Z

Ah505: /* Structure */

It:Flucloxacillin

2006-11-23T15:56:15Z

Ah505: /* 3D Structure */

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==
<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 Cl 0 -5.120 -0.524 -1.526 0.00 0.00 Cl+0
ATOM 2 C 0 -4.115 -1.368 -0.391 0.00 0.00 C+0
ATOM 3 C 0 -3.205 -0.663 0.397 0.00 0.00 C+0
ATOM 4 C 0 -3.094 0.810 0.268 0.00 0.00 C+0
ATOM 5 N 0 -4.067 1.671 0.109 0.00 0.00 N+0
ATOM 6 O 0 -3.662 2.805 0.036 0.00 0.00 O+0
ATOM 7 C 0 -2.334 2.901 0.133 0.00 0.00 C+0
ATOM 8 C 0 -1.516 4.165 0.080 0.00 0.00 C+0
ATOM 9 C 0 -1.860 1.624 0.297 0.00 0.00 C+0
ATOM 10 C 0 -0.467 1.174 0.454 0.00 0.00 C+0
ATOM 11 N 0 0.264 0.854 -0.632 0.00 0.00 N+0
ATOM 12 C 0 1.650 0.406 -0.476 0.00 0.00 C+0
ATOM 13 H 0 1.843 -0.041 0.499 0.00 0.00 H+0
ATOM 14 C 0 2.688 1.466 -0.883 0.00 0.00 C+0
ATOM 15 N 0 3.399 0.383 -1.586 0.00 0.00 N+0
ATOM 16 C 0 2.160 -0.444 -1.656 0.00 0.00 C+0
ATOM 17 S 0 2.796 -2.082 -1.082 0.00 0.00 S+0
ATOM 18 C 0 4.107 -1.412 0.038 0.00 0.00 C+0
ATOM 19 C 0 3.550 -1.114 1.431 0.00 0.00 C+0
ATOM 20 C 0 5.310 -2.354 0.113 0.00 0.00 C+0
ATOM 21 C 0 4.458 -0.107 -0.721 0.00 0.00 C+0
ATOM 22 H 0 5.346 -0.287 -1.327 0.00 0.00 H+0
ATOM 23 C 0 4.779 0.963 0.290 0.00 0.00 C+0
ATOM 24 O 0 4.973 2.229 -0.111 0.00 0.00 O+0
ATOM 25 O 0 4.862 0.682 1.462 0.00 0.00 O+0
ATOM 26 O 0 0.024 1.092 1.563 0.00 0.00 O+0
ATOM 27 C 0 -2.401 -1.350 1.308 0.00 0.00 C+0
ATOM 28 F 0 -1.517 -0.674 2.075 0.00 0.00 F+0
ATOM 29 C 0 -2.510 -2.723 1.423 0.00 0.00 C+0
ATOM 30 C 0 -3.414 -3.416 0.639 0.00 0.00 C+0
ATOM 31 C 0 -4.218 -2.740 -0.262 0.00 0.00 C+0
ATOM 32 H 0 -2.178 5.021 -0.054 0.00 0.00 H+0
ATOM 33 H 0 -0.960 4.278 1.011 0.00 0.00 H+0
ATOM 34 H 0 -0.818 4.112 -0.756 0.00 0.00 H+0
ATOM 35 H 0 -0.128 0.919 -1.517 0.00 0.00 H+0
ATOM 36 H 0 2.292 2.233 -1.549 0.00 0.00 H+0
ATOM 37 H 0 3.244 1.879 -0.042 0.00 0.00 H+0
ATOM 38 H 0 1.576 -0.433 -2.576 0.00 0.00 H+0
ATOM 39 H 0 2.837 -1.889 1.711 0.00 0.00 H+0
ATOM 40 H 0 4.367 -1.093 2.152 0.00 0.00 H+0
ATOM 41 H 0 3.049 -0.146 1.423 0.00 0.00 H+0
ATOM 42 H 0 5.720 -2.501 -0.886 0.00 0.00 H+0
ATOM 43 H 0 6.072 -1.919 0.759 0.00 0.00 H+0
ATOM 44 H 0 4.994 -3.315 0.521 0.00 0.00 H+0
ATOM 45 H 0 5.180 2.916 0.537 0.00 0.00 H+0
ATOM 46 H 0 -1.888 -3.256 2.127 0.00 0.00 H+0
ATOM 47 H 0 -3.496 -4.488 0.732 0.00 0.00 H+0
ATOM 48 H 0 -4.922 -3.287 -0.871 0.00 0.00 H+0
CONECT 1 2 0 0 0 NONE 53
CONECT 2 1 31 3 0 NONE 54
CONECT 3 2 4 27 0 NONE 55
CONECT 4 3 9 5 0 NONE 56
CONECT 5 4 6 0 0 NONE 57
CONECT 6 5 7 0 0 NONE 58
CONECT 7 6 8 9 0 NONE 59
CONECT 8 7 32 33 34 NONE 60
CONECT 9 7 4 10 0 NONE 61
CONECT 10 9 11 26 0 NONE 62
CONECT 11 10 12 35 0 NONE 63
CONECT 12 11 13 16 14 NONE 64
CONECT 14 12 15 36 37 NONE 65
CONECT 15 14 21 16 0 NONE 66
CONECT 16 15 12 17 38 NONE 67
CONECT 17 16 18 0 0 NONE 68
CONECT 18 17 19 20 21 NONE 69
CONECT 19 18 39 40 41 NONE 70
CONECT 20 18 42 43 44 NONE 71
CONECT 21 18 22 15 23 NONE 72
CONECT 23 21 24 25 0 NONE 73
CONECT 24 23 45 0 0 NONE 74
CONECT 25 23 0 0 0 NONE 75
CONECT 26 10 0 0 0 NONE 76
CONECT 27 3 28 29 0 NONE 77
CONECT 28 27 0 0 0 NONE 78
CONECT 29 27 30 46 0 NONE 79
CONECT 30 29 31 47 0 NONE 80
CONECT 31 30 2 48 0 NONE 81
END NONE 82

</inlineContents>
</jmolApplet>
</jmol>

It:Flucloxacillin

2006-11-23T15:51:37Z

Ah505: /* Structure */

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

It:Flucloxacillin

2006-11-23T15:49:12Z

Ah505:

== Structure ==
[[Image:flucloxacillin.gif|centre|100|image produced in chemdraw]]

File:Flucloxacillin.gif

2006-11-23T15:46:16Z

Ah505:

It:projects

2006-11-23T15:38:44Z

Ah505: /* Supplemental Project Page */

__FORCETOC__

'''''You MUST use the Edit buttons on the right to edit this content. Do NOT use the Edit button on the top of this page.'''''
== Sandbox (Play-Pen) ==

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It:Lipitor

2006-11-20T16:03:39Z

Ah505: /* Reference Link */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.
[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Synthesis ==
[[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]

== Structure ==

[[Image:lipitor3.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0
ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0
ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0
ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0
ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0
ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0
ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0
ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0
ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0
ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1
ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0
ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0
ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0
ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0
ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0
ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0
ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0
ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0
ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0
ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0
ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0
ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0
ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0
ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0
ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0
ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0
ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0
ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0
ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0
ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0
ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0
ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0
ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0
ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0
ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0
ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0
ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0
ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0
ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0
ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0
ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0
ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0
ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0
ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0
ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0
ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0
ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0
ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0
ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0
ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0
ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0
ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0
ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0
ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0
ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0
ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0
ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0
ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0
ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0
ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0
ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0
ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0
ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0
ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0
ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0
ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0
CONECT 1 2 41 0 0 NONE 71
CONECT 2 1 3 4 12 NONE 72
CONECT 4 2 5 42 43 NONE 73
CONECT 5 4 6 7 8 NONE 74
CONECT 7 5 44 0 0 NONE 75
CONECT 8 5 9 45 46 NONE 76
CONECT 9 8 10 11 0 NONE 77
CONECT 10 9 0 0 0 NONE 78
CONECT 11 9 0 0 0 NONE 79
CONECT 12 2 13 47 48 NONE 80
CONECT 13 12 14 49 50 NONE 81
CONECT 14 13 15 26 0 NONE 82
CONECT 15 14 16 51 0 NONE 83
CONECT 16 15 27 17 0 NONE 84
CONECT 17 16 18 25 0 NONE 85
CONECT 18 17 19 52 0 NONE 86
CONECT 19 18 24 20 0 NONE 87
CONECT 20 19 21 53 0 NONE 88
CONECT 21 20 22 54 0 NONE 89
CONECT 22 21 23 55 0 NONE 90
CONECT 23 22 24 56 0 NONE 91
CONECT 24 23 19 57 0 NONE 92
CONECT 25 17 0 0 0 NONE 93
CONECT 26 14 27 58 0 NONE 94
CONECT 27 26 16 28 0 NONE 95
CONECT 28 27 33 29 0 NONE 96
CONECT 29 28 30 59 0 NONE 97
CONECT 30 29 31 60 0 NONE 98
CONECT 31 30 32 61 0 NONE 99
CONECT 32 31 33 62 0 NONE 100
CONECT 33 32 28 34 0 NONE 101
CONECT 34 33 40 35 0 NONE 102
CONECT 35 34 36 63 0 NONE 103
CONECT 36 35 37 64 0 NONE 104
CONECT 37 36 38 39 0 NONE 105
CONECT 38 37 0 0 0 NONE 106
CONECT 39 37 40 65 0 NONE 107
CONECT 40 39 34 66 0 NONE 108
END NONE 109
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

== Reference Link ==

*[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]
*http://www.drugs.com/lipitor.html
*http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm
*http://organicdivision.org/essays_2001/schaus.pdf
*http://www.molecular-networks.com/online_demos/corina_demo.html

It:Lipitor

2006-11-20T16:00:17Z

Ah505: /* 3D Structure */

It:Lipitor

2006-11-20T15:59:46Z

Ah505: /* 3D Structure */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.
[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Synthesis ==
[[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]

== Structure ==

[[Image:lipitor3.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>800</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -4.424 1.493 1.749 0.00 0.00 O+0
ATOM 2 C 0 -4.300 0.218 1.115 0.00 0.00 C+0
ATOM 3 H 0 -4.644 -0.561 1.796 0.00 0.00 H+0
ATOM 4 C 0 -5.150 0.196 -0.157 0.00 0.00 C+0
ATOM 5 C 0 -6.629 0.321 0.216 0.00 0.00 C+0
ATOM 6 H 0 -6.891 -0.462 0.928 0.00 0.00 H+0
ATOM 7 O 0 -6.865 1.601 0.806 0.00 0.00 O+0
ATOM 8 C 0 -7.486 0.174 -1.043 0.00 0.00 C+0
ATOM 9 C 0 -8.944 0.174 -0.661 0.00 0.00 C+0
ATOM 10 O 0 -9.267 0.281 0.510 0.00 0.00 O-1
ATOM 11 O 0 -9.800 0.066 -1.522 0.00 0.00 O+0
ATOM 12 C 0 -2.834 -0.031 0.753 0.00 0.00 C+0
ATOM 13 C 0 -2.003 -0.133 2.034 0.00 0.00 C+0
ATOM 14 N 0 -0.600 -0.372 1.688 0.00 0.00 N+0
ATOM 15 C 0 0.314 0.596 1.478 0.00 0.00 C+0
ATOM 16 C 0 1.511 0.010 1.177 0.00 0.00 C+0
ATOM 17 C 0 2.779 0.692 0.877 0.00 0.00 C+0
ATOM 18 N 0 2.820 2.037 0.803 0.00 0.00 N+0
ATOM 19 C 0 4.044 2.691 0.633 0.00 0.00 C+0
ATOM 20 C 0 4.117 3.842 -0.142 0.00 0.00 C+0
ATOM 21 C 0 5.328 4.485 -0.307 0.00 0.00 C+0
ATOM 22 C 0 6.467 3.986 0.297 0.00 0.00 C+0
ATOM 23 C 0 6.398 2.841 1.069 0.00 0.00 C+0
ATOM 24 C 0 5.189 2.196 1.244 0.00 0.00 C+0
ATOM 25 O 0 3.791 0.042 0.696 0.00 0.00 O+0
ATOM 26 C 0 -0.036 -1.603 1.539 0.00 0.00 C+0
ATOM 27 C 0 1.274 -1.445 1.215 0.00 0.00 C+0
ATOM 28 C 0 2.265 -2.516 0.962 0.00 0.00 C+0
ATOM 29 C 0 2.666 -3.357 1.997 0.00 0.00 C+0
ATOM 30 C 0 3.590 -4.354 1.756 0.00 0.00 C+0
ATOM 31 C 0 4.122 -4.525 0.489 0.00 0.00 C+0
ATOM 32 C 0 3.735 -3.700 -0.548 0.00 0.00 C+0
ATOM 33 C 0 2.800 -2.693 -0.325 0.00 0.00 C+0
ATOM 34 C 0 2.381 -1.806 -1.435 0.00 0.00 C+0
ATOM 35 C 0 3.336 -1.099 -2.164 0.00 0.00 C+0
ATOM 36 C 0 2.941 -0.274 -3.197 0.00 0.00 C+0
ATOM 37 C 0 1.597 -0.146 -3.510 0.00 0.00 C+0
ATOM 38 F 0 1.215 0.663 -4.522 0.00 0.00 F+0
ATOM 39 C 0 0.644 -0.847 -2.788 0.00 0.00 C+0
ATOM 40 C 0 1.030 -1.679 -1.757 0.00 0.00 C+0
ATOM 41 H 0 -4.110 2.152 1.115 0.00 0.00 H+0
ATOM 42 H 0 -4.865 1.030 -0.798 0.00 0.00 H+0
ATOM 43 H 0 -4.987 -0.742 -0.687 0.00 0.00 H+0
ATOM 44 H 0 -6.621 2.263 0.145 0.00 0.00 H+0
ATOM 45 H 0 -7.287 1.007 -1.717 0.00 0.00 H+0
ATOM 46 H 0 -7.241 -0.764 -1.542 0.00 0.00 H+0
ATOM 47 H 0 -2.752 -0.961 0.192 0.00 0.00 H+0
ATOM 48 H 0 -2.465 0.795 0.145 0.00 0.00 H+0
ATOM 49 H 0 -2.086 0.798 2.596 0.00 0.00 H+0
ATOM 50 H 0 -2.373 -0.958 2.642 0.00 0.00 H+0
ATOM 51 H 0 0.130 1.659 1.537 0.00 0.00 H+0
ATOM 52 H 0 2.000 2.551 0.867 0.00 0.00 H+0
ATOM 53 H 0 3.228 4.232 -0.615 0.00 0.00 H+0
ATOM 54 H 0 5.385 5.380 -0.910 0.00 0.00 H+0
ATOM 55 H 0 7.412 4.491 0.166 0.00 0.00 H+0
ATOM 56 H 0 7.289 2.453 1.540 0.00 0.00 H+0
ATOM 57 H 0 5.136 1.301 1.847 0.00 0.00 H+0
ATOM 58 H 0 -0.546 -2.547 1.656 0.00 0.00 H+0
ATOM 59 H 0 2.256 -3.229 2.987 0.00 0.00 H+0
ATOM 60 H 0 3.900 -5.005 2.560 0.00 0.00 H+0
ATOM 61 H 0 4.845 -5.308 0.311 0.00 0.00 H+0
ATOM 62 H 0 4.154 -3.838 -1.534 0.00 0.00 H+0
ATOM 63 H 0 4.384 -1.197 -1.921 0.00 0.00 H+0
ATOM 64 H 0 3.681 0.274 -3.762 0.00 0.00 H+0
ATOM 65 H 0 -0.402 -0.744 -3.035 0.00 0.00 H+0
ATOM 66 H 0 0.286 -2.224 -1.195 0.00 0.00 H+0
CONECT 1 2 41 0 0 NONE 71
CONECT 2 1 3 4 12 NONE 72
CONECT 4 2 5 42 43 NONE 73
CONECT 5 4 6 7 8 NONE 74
CONECT 7 5 44 0 0 NONE 75
CONECT 8 5 9 45 46 NONE 76
CONECT 9 8 10 11 0 NONE 77
CONECT 10 9 0 0 0 NONE 78
CONECT 11 9 0 0 0 NONE 79
CONECT 12 2 13 47 48 NONE 80
CONECT 13 12 14 49 50 NONE 81
CONECT 14 13 15 26 0 NONE 82
CONECT 15 14 16 51 0 NONE 83
CONECT 16 15 27 17 0 NONE 84
CONECT 17 16 18 25 0 NONE 85
CONECT 18 17 19 52 0 NONE 86
CONECT 19 18 24 20 0 NONE 87
CONECT 20 19 21 53 0 NONE 88
CONECT 21 20 22 54 0 NONE 89
CONECT 22 21 23 55 0 NONE 90
CONECT 23 22 24 56 0 NONE 91
CONECT 24 23 19 57 0 NONE 92
CONECT 25 17 0 0 0 NONE 93
CONECT 26 14 27 58 0 NONE 94
CONECT 27 26 16 28 0 NONE 95
CONECT 28 27 33 29 0 NONE 96
CONECT 29 28 30 59 0 NONE 97
CONECT 30 29 31 60 0 NONE 98
CONECT 31 30 32 61 0 NONE 99
CONECT 32 31 33 62 0 NONE 100
CONECT 33 32 28 34 0 NONE 101
CONECT 34 33 40 35 0 NONE 102
CONECT 35 34 36 63 0 NONE 103
CONECT 36 35 37 64 0 NONE 104
CONECT 37 36 38 39 0 NONE 105
CONECT 38 37 0 0 0 NONE 106
CONECT 39 37 40 65 0 NONE 107
CONECT 40 39 34 66 0 NONE 108
END NONE 109
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

== Reference Link ==

*[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop Lipitor Main Page]
*http://www.drugs.com/lipitor.html
*http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm
*http://organicdivision.org/essays_2001/schaus.pdf

It:Lipitor

2006-11-20T15:56:06Z

Ah505: /* Structure */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.
[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Synthesis ==
[[Image:atorvastatin synthesis.JPG]][http://organicdivision.org/essays_2001/schaus.pdf Synthesis]

== Structure ==

[[Image:lipitor3.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>800</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

File:Lipitor3.gif

2006-11-20T15:55:37Z

Ah505:

It:Lipitor

2006-11-20T15:50:16Z

Ah505:

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular disease.
[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.
== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>800</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

It:Lipitor

2006-11-20T15:47:18Z

Ah505: /* How does it works */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol. Lipitor is also used to increase levels of HDL (good) cholesterol in the blood. This is important as it reduces the risk of hardening arteries which can lead to heart attacks, strokes and peripheral vascular dicease.

== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>800</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

It:Lipitor

2006-11-20T15:41:13Z

Ah505: /* 3D Structure */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>800</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

It:Lipitor

2006-11-20T15:35:19Z

Ah505: /* 3D Structure */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>500</size>
<color>white</color>
<script>zoom 80; cpk on;frame 1; move 10 -20 10 0 0 0 0 0 3; delay 1;</script>
<inlineContents>water.mol
title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
</inlineContents>
</jmolApplet>
</jmol>

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

It:Lipitor

2006-11-20T15:34:33Z

Ah505: /* Structure */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |Systematic IUPAC Name
|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== 3D Structure ==

<jmol>
<jmolApplet>
<size>400</size>
<color>white</color>
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title1
title2
ATOM 1 O 0 -3.927 1.335 1.405 0.00 0.00 O+0
ATOM 2 C 0 -3.862 0.102 0.685 0.00 0.00 C+0
ATOM 3 H 0 -4.179 -0.714 1.333 0.00 0.00 H+0
ATOM 4 C 0 -4.784 0.174 -0.534 0.00 0.00 C+0
ATOM 5 C 0 -6.236 0.294 -0.068 0.00 0.00 C+0
ATOM 6 H 0 -6.471 -0.530 0.607 0.00 0.00 H+0
ATOM 7 O 0 -6.416 1.536 0.616 0.00 0.00 O+0
ATOM 8 C 0 -7.167 0.240 -1.281 0.00 0.00 C+0
ATOM 9 C 0 -8.600 0.234 -0.815 0.00 0.00 C+0
ATOM 10 O 0 -8.854 0.270 0.378 0.00 0.00 O-1
ATOM 11 O 0 -9.507 0.194 -1.630 0.00 0.00 O+0
ATOM 12 C 0 -2.424 -0.143 0.223 0.00 0.00 C+0
ATOM 13 C 0 -1.522 -0.338 1.443 0.00 0.00 C+0
ATOM 14 N 0 -0.145 -0.573 1.001 0.00 0.00 N+0
ATOM 15 C 0 0.771 0.394 0.800 0.00 0.00 C+0
ATOM 16 C 0 1.938 -0.188 0.393 0.00 0.00 C+0
ATOM 17 C 0 3.199 0.495 0.063 0.00 0.00 C+0
ATOM 18 N 0 3.282 1.837 0.150 0.00 0.00 N+0
ATOM 19 C 0 4.509 2.477 -0.052 0.00 0.00 C+0
ATOM 20 C 0 4.550 3.735 -0.638 0.00 0.00 C+0
ATOM 21 C 0 5.763 4.364 -0.836 0.00 0.00 C+0
ATOM 22 C 0 6.937 3.742 -0.451 0.00 0.00 C+0
ATOM 23 C 0 6.900 2.489 0.133 0.00 0.00 C+0
ATOM 24 C 0 5.689 1.858 0.340 0.00 0.00 C+0
ATOM 25 O 0 4.168 -0.153 -0.288 0.00 0.00 O+0
ATOM 26 C 0 0.388 -1.799 0.741 0.00 0.00 C+0
ATOM 27 C 0 1.678 -1.638 0.352 0.00 0.00 C+0
ATOM 28 C 0 2.635 -2.705 -0.028 0.00 0.00 C+0
ATOM 29 C 0 2.815 -3.812 0.800 0.00 0.00 C+0
ATOM 30 C 0 3.706 -4.802 0.442 0.00 0.00 C+0
ATOM 31 C 0 4.421 -4.698 -0.738 0.00 0.00 C+0
ATOM 32 C 0 4.247 -3.602 -1.564 0.00 0.00 C+0
ATOM 33 C 0 3.354 -2.609 -1.219 0.00 0.00 C+0
ATOM 34 H 0 -3.639 2.030 0.797 0.00 0.00 H+0
ATOM 35 H 0 -4.523 1.044 -1.137 0.00 0.00 H+0
ATOM 36 H 0 -4.667 -0.731 -1.131 0.00 0.00 H+0
ATOM 37 H 0 -6.199 2.236 -0.015 0.00 0.00 H+0
ATOM 38 H 0 -6.993 1.112 -1.911 0.00 0.00 H+0
ATOM 39 H 0 -6.967 -0.667 -1.852 0.00 0.00 H+0
ATOM 40 H 0 -2.390 -1.036 -0.401 0.00 0.00 H+0
ATOM 41 H 0 -2.076 0.716 -0.352 0.00 0.00 H+0
ATOM 42 H 0 -1.556 0.555 2.067 0.00 0.00 H+0
ATOM 43 H 0 -1.870 -1.196 2.018 0.00 0.00 H+0
ATOM 44 H 0 0.610 1.453 0.937 0.00 0.00 H+0
ATOM 45 H 0 2.490 2.359 0.352 0.00 0.00 H+0
ATOM 46 H 0 3.633 4.221 -0.940 0.00 0.00 H+0
ATOM 47 H 0 5.796 5.343 -1.292 0.00 0.00 H+0
ATOM 48 H 0 7.884 4.236 -0.607 0.00 0.00 H+0
ATOM 49 H 0 7.818 2.006 0.432 0.00 0.00 H+0
ATOM 50 H 0 5.661 0.879 0.796 0.00 0.00 H+0
ATOM 51 H 0 -0.131 -2.742 0.827 0.00 0.00 H+0
ATOM 52 H 0 2.257 -3.893 1.722 0.00 0.00 H+0
ATOM 53 H 0 3.846 -5.659 1.083 0.00 0.00 H+0
ATOM 54 H 0 5.118 -5.475 -1.015 0.00 0.00 H+0
ATOM 55 H 0 4.809 -3.526 -2.484 0.00 0.00 H+0
ATOM 56 H 0 3.219 -1.754 -1.865 0.00 0.00 H+0
CONECT 1 2 34 0 0 NONE 61
CONECT 2 1 3 4 12 NONE 62
CONECT 4 2 5 35 36 NONE 63
CONECT 5 4 6 7 8 NONE 64
CONECT 7 5 37 0 0 NONE 65
CONECT 8 5 9 38 39 NONE 66
CONECT 9 8 10 11 0 NONE 67
CONECT 10 9 0 0 0 NONE 68
CONECT 11 9 0 0 0 NONE 69
CONECT 12 2 13 40 41 NONE 70
CONECT 13 12 14 42 43 NONE 71
CONECT 14 13 15 26 0 NONE 72
CONECT 15 14 16 44 0 NONE 73
CONECT 16 15 27 17 0 NONE 74
CONECT 17 16 18 25 0 NONE 75
CONECT 18 17 19 45 0 NONE 76
CONECT 19 18 24 20 0 NONE 77
CONECT 20 19 21 46 0 NONE 78
CONECT 21 20 22 47 0 NONE 79
CONECT 22 21 23 48 0 NONE 80
CONECT 23 22 24 49 0 NONE 81
CONECT 24 23 19 50 0 NONE 82
CONECT 25 17 0 0 0 NONE 83
CONECT 26 14 27 51 0 NONE 84
CONECT 27 26 16 28 0 NONE 85
CONECT 28 27 33 29 0 NONE 86
CONECT 29 28 30 52 0 NONE 87
CONECT 30 29 31 53 0 NONE 88
CONECT 31 30 32 54 0 NONE 89
CONECT 32 31 33 55 0 NONE 90
CONECT 33 32 28 56 0 NONE 91
END NONE 92
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== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

It:Lipitor

2006-11-20T15:27:06Z

Ah505: /* How does it works */

{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"
! {{chembox header}} colspan="3" |2D Structure of Lipitor(Atorvastatin)
|-
| align="center" colspan="3" bgcolor="#ffffff" | [[ ]]

|-
| align="center" colspan="3" bgcolor="#ffffff" |
|-

|-
| Systematic Iupac Name
| colspan="2"| [R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid|-
|-
! {{chembox header}} colspan="3"| Identifiers
|-
| CAS registry number|CAS number
| colspan="2" | 134523-00-5
|-
| CAS registry number|ATC Code
| colspan="2" | C10AA05
|-
| CAS registry number|Pub Chem
| colspan="2" | 60823
|-
| CAS registry number|Drug Bank
| colspan="2" | APRD00055
|-
|-
! {{chembox header}} colspan="3"| Chemical Data
|-
| Chemical formula|Molecular formula
| colspan="2" | C<sub>33</sub>H<sub>34</sub>N<sub>2</sub>O<sub>5</sub>F
|-
| Molar mass
| colspan="2" | 558.64 g/mol
|-

|}

Lipitor (Atorvastatin) is a cholesterol-lowering medication (a type of HMG CoA reductase inhibitor) which belongs to a lass of medicine called statins.It was introduced in 1997. It is used to block the production of cholesterol in the human body. It lowers your cholesterol level and reduces the risk of heart attacks and strokes.[http://www.lipitor.com/cwp/appmanager/lipitor/lipitorDesktop 1]

== How does it works ==

LDL (low density lipoprotein) cholesterol can cause a buildup of plaque in the human artery, constricting the blood flow, thus induces atherosclerosis (thickening of the arteries). Lipitor will inhibit an enzyme in the liver (hepatic tissue) which is used to produce the LDL cholesterol.

== Structure ==

[[Image:lipitor2.gif|centre|100|image produced in chemdraw]]

== Health Complication ==

Lipitor have been associated to some with muscle pain and Liver problems. The symptoms occuring due to these health issues includes muscle pain, feverlike symptoms, abdominal pain, fatique, or dark coloured urine

Lipitor can cause a number of side effect:[http://medguides.medicines.org.uk/displaypage.aspx?i=69&t=medicine side effect]
*allergic reaction
*loss of appetite
*bruising
*chest pain
*headache
*itching
*difficulty with memory/ thinking
*numbness in hand and feet

There have been numerous adverse side effect reports that lipitor could have been the cause of neuromuscular degeneration (losing control of muscle movement)[http://www.newmediaexplorer.org/sepp/2004/03/18/lipitor_side_effects_and_natural_remedy.htm 2]

File:Lipitor2.gif

2006-11-20T15:24:08Z

Ah505:

File:Lipitor.gif

2006-11-20T15:10:38Z

Ah505: